Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | ROPN1B | rhophilin associated tail protein 1B (212 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | SERHL2 | serine hydrolase-like 2; Probable serine hydrolase. May be related to cell muscle hypertrophy (314 aa) |
 |
0.586 | ||||||||||
 | FSIP2 | fibrous sheath interacting protein 2 (6996 aa) |
|
0.584 | ||||||||||
 | FSIP1 | fibrous sheath interacting protein 1 (581 aa) |
|
0.584 | ||||||||||
 | AKAP3 | A kinase (PRKA) anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction (853 aa) |
|
0.564 | ||||||||||
 | ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 (385 aa) |
|
0.504 | ||||||||||
 | AKAP4 | A kinase (PRKA) anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility (854 aa) |
|
0.482 | ||||||||||
 | UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active (529 aa) |
|
0.478 | ||||||||||
 | ART3 | ADP-ribosyltransferase 3 (389 aa) |
|
0.465 | ||||||||||
 | TNPO3 | transportin 3; Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains (923 aa) |
|
0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
