CARD10 protein (Homo sapiens) - STRING network view

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CARD10

caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK (1032 aa)

Predicted Functional Partners:

BCL10

0.999

MALT1

0.972

IKBKG

0.943

POLR2F

0.899

CAD

0.850

UMPS

0.814

AMOTL1

0.809

UBC

0.808

KRT16

0.800

LIN7A

0.766

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOTL1	CARD10	ENSP00000387739	ENSP00000251973	angiomotin like 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	0.809
AMOTL1	KRT16	ENSP00000387739	ENSP00000301653	angiomotin like 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus	keratin 16	0.803
AMOTL1	UBC	ENSP00000387739	ENSP00000344818	angiomotin like 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus	ubiquitin C	0.959
BCL10	CARD10	ENSP00000271015	ENSP00000251973	B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	0.999
BCL10	IKBKG	ENSP00000271015	ENSP00000358622	B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...]	0.999
BCL10	MALT1	ENSP00000271015	ENSP00000319279	B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion	0.999
BCL10	UBC	ENSP00000271015	ENSP00000344818	B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	ubiquitin C	0.987
CAD	CARD10	ENSP00000264705	ENSP00000251973	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	0.850
CAD	POLR2F	ENSP00000264705	ENSP00000403852	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	polymerase (RNA) II (DNA directed) polypeptide F; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp ele [...]	0.646
CAD	UBC	ENSP00000264705	ENSP00000344818	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	ubiquitin C	0.874
CAD	UMPS	ENSP00000264705	ENSP00000232607	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	uridine monophosphate synthetase	0.998
CARD10	AMOTL1	ENSP00000251973	ENSP00000387739	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	angiomotin like 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus	0.809
CARD10	BCL10	ENSP00000251973	ENSP00000271015	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	0.999
CARD10	CAD	ENSP00000251973	ENSP00000264705	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	0.850
CARD10	IKBKG	ENSP00000251973	ENSP00000358622	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...]	0.943
CARD10	KRT16	ENSP00000251973	ENSP00000301653	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	keratin 16	0.800
CARD10	LIN7A	ENSP00000251973	ENSP00000447488	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.766
CARD10	MALT1	ENSP00000251973	ENSP00000319279	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	mucosa associated lymphoid tissue lymphoma translocation gene 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion	0.972
CARD10	POLR2F	ENSP00000251973	ENSP00000403852	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	polymerase (RNA) II (DNA directed) polypeptide F; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp ele [...]	0.899
CARD10	UBC	ENSP00000251973	ENSP00000344818	caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK	ubiquitin C	0.808

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