node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMWD | TRMT2A | ENSP00000270223 | ENSP00000252136 | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis | tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications | 0.779 |
ENSG00000257411 | NOP2 | ENSP00000449770 | ENSP00000382392 | Uncharacterized protein | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.932 |
ENSG00000257411 | NSUN6 | ENSP00000449770 | ENSP00000366519 | Uncharacterized protein | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.932 |
ENSG00000257411 | RANBP1 | ENSP00000449770 | ENSP00000327583 | Uncharacterized protein | RAN binding protein 1; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane | 0.422 |
ENSG00000257411 | TRMT1 | ENSP00000449770 | ENSP00000350352 | Uncharacterized protein | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.849 |
ENSG00000257411 | TRMT11 | ENSP00000449770 | ENSP00000333934 | Uncharacterized protein | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.805 |
ENSG00000257411 | TRMT1L | ENSP00000449770 | ENSP00000356476 | Uncharacterized protein | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.849 |
ENSG00000257411 | TRMT2A | ENSP00000449770 | ENSP00000252136 | Uncharacterized protein | tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications | 0.736 |
NOP2 | ENSG00000257411 | ENSP00000382392 | ENSP00000449770 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | Uncharacterized protein | 0.932 |
NOP2 | TRMT1 | ENSP00000382392 | ENSP00000350352 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.820 |
NOP2 | TRMT11 | ENSP00000382392 | ENSP00000333934 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.831 |
NOP2 | TRMT1L | ENSP00000382392 | ENSP00000356476 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.814 |
NOP2 | TRMT2A | ENSP00000382392 | ENSP00000252136 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications | 0.786 |
NOP2 | TRMT5 | ENSP00000382392 | ENSP00000261249 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.436 |
NSUN6 | ENSG00000257411 | ENSP00000366519 | ENSP00000449770 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | Uncharacterized protein | 0.932 |
NSUN6 | TRMT1 | ENSP00000366519 | ENSP00000350352 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.825 |
NSUN6 | TRMT11 | ENSP00000366519 | ENSP00000333934 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.829 |
NSUN6 | TRMT1L | ENSP00000366519 | ENSP00000356476 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.850 |
NSUN6 | TRMT2A | ENSP00000366519 | ENSP00000252136 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications | 0.831 |
RAD52 | TRMT2A | ENSP00000351284 | ENSP00000252136 | RAD52 homolog (S. cerevisiae); Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase | tRNA methyltransferase 2 homolog A (S. cerevisiae); May be involved in nucleic acid metabolism and/or modifications | 0.786 |