Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MYH13 | myosin, heavy chain 13, skeletal muscle; Muscle contraction (1938 aa) | ||||||||||||
Predicted Functional Partners:
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 | ACTB | actin, beta (375 aa) |
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0.925 | |||||||
 | MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction (1937 aa) |
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0.901 | ||||||||
 | MYH2 | myosin, heavy chain 2, skeletal muscle, adult; Muscle contraction. Required for cytoskeleton organization (By similarity) (1941 aa) |
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0.901 | ||||||||
 | MYH6 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa) |
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0.900 | ||||||||
 | MYH1 | myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction (1939 aa) |
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0.900 | ||||||||
 | MYH7 | myosin, heavy chain 7, cardiac muscle, beta (1935 aa) |
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0.900 | ||||||||
 | MYL9 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (172 aa) |
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0.876 | |||||||
 | MYL5 | myosin, light chain 5, regulatory (173 aa) |
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0.872 | |||||||
 | MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle (169 aa) |
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0.872 | |||||||
 | CGN | cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (1203 aa) |
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0.800 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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