node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CORO1B | DKK2 | ENSP00000340211 | ENSP00000285311 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | 0.585 |
CORO1B | KRT6C | ENSP00000340211 | ENSP00000252250 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | keratin 6C | 0.523 |
CORO1B | MEGF10 | ENSP00000340211 | ENSP00000274473 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.585 |
CORO1B | MEGF11 | ENSP00000340211 | ENSP00000386908 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) | 0.585 |
CORO1B | MEGF6 | ENSP00000340211 | ENSP00000348982 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | multiple EGF-like-domains 6 | 0.585 |
CORO1B | PEAR1 | ENSP00000340211 | ENSP00000292357 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity) | 0.585 |
CORO1B | SCARF1 | ENSP00000340211 | ENSP00000263071 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | scavenger receptor class F, member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity) | 0.585 |
CORO1B | SCARF2 | ENSP00000340211 | ENSP00000266214 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | scavenger receptor class F, member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity) | 0.585 |
CORO1B | TNFAIP6 | ENSP00000340211 | ENSP00000243347 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.606 |
CORO1B | UBC | ENSP00000340211 | ENSP00000344818 | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | ubiquitin C | 0.890 |
DKK2 | CORO1B | ENSP00000285311 | ENSP00000340211 | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | 0.585 |
DKK2 | KRT6C | ENSP00000285311 | ENSP00000252250 | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | keratin 6C | 0.542 |
KRT6C | CORO1B | ENSP00000252250 | ENSP00000340211 | keratin 6C | coronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) | 0.523 |
KRT6C | DKK2 | ENSP00000252250 | ENSP00000285311 | keratin 6C | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | 0.542 |
KRT6C | MEGF10 | ENSP00000252250 | ENSP00000274473 | keratin 6C | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.542 |
KRT6C | MEGF11 | ENSP00000252250 | ENSP00000386908 | keratin 6C | multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) | 0.542 |
KRT6C | MEGF6 | ENSP00000252250 | ENSP00000348982 | keratin 6C | multiple EGF-like-domains 6 | 0.542 |
KRT6C | PEAR1 | ENSP00000252250 | ENSP00000292357 | keratin 6C | platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity) | 0.542 |
KRT6C | SCARF1 | ENSP00000252250 | ENSP00000263071 | keratin 6C | scavenger receptor class F, member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity) | 0.542 |
KRT6C | SCARF2 | ENSP00000252250 | ENSP00000266214 | keratin 6C | scavenger receptor class F, member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity) | 0.542 |