node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DKK2 | KRT6B | ENSP00000285311 | ENSP00000252252 | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | keratin 6B | 0.542 |
EIF4A3 | KRT14 | ENSP00000269349 | ENSP00000167586 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | 0.601 |
EIF4A3 | KRT6B | ENSP00000269349 | ENSP00000252252 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | keratin 6B | 0.601 |
EIF4A3 | UBC | ENSP00000269349 | ENSP00000344818 | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | ubiquitin C | 0.994 |
KRT14 | EIF4A3 | ENSP00000167586 | ENSP00000269349 | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | 0.601 |
KRT14 | KRT6B | ENSP00000167586 | ENSP00000252252 | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | keratin 6B | 0.563 |
KRT14 | UBC | ENSP00000167586 | ENSP00000344818 | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | ubiquitin C | 0.739 |
KRT6B | DKK2 | ENSP00000252252 | ENSP00000285311 | keratin 6B | dickkopf 2 homolog (Xenopus laevis); Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) | 0.542 |
KRT6B | EIF4A3 | ENSP00000252252 | ENSP00000269349 | keratin 6B | eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] | 0.601 |
KRT6B | KRT14 | ENSP00000252252 | ENSP00000167586 | keratin 6B | keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro | 0.563 |
KRT6B | MEGF10 | ENSP00000252252 | ENSP00000274473 | keratin 6B | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | 0.542 |
KRT6B | MEGF11 | ENSP00000252252 | ENSP00000386908 | keratin 6B | multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) | 0.542 |
KRT6B | MEGF6 | ENSP00000252252 | ENSP00000348982 | keratin 6B | multiple EGF-like-domains 6 | 0.542 |
KRT6B | PEAR1 | ENSP00000252252 | ENSP00000292357 | keratin 6B | platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells (By similarity) | 0.542 |
KRT6B | SCARF2 | ENSP00000252252 | ENSP00000266214 | keratin 6B | scavenger receptor class F, member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity) | 0.542 |
KRT6B | TNFAIP6 | ENSP00000252252 | ENSP00000243347 | keratin 6B | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.547 |
KRT6B | UBC | ENSP00000252252 | ENSP00000344818 | keratin 6B | ubiquitin C | 0.858 |
MEGF10 | KRT6B | ENSP00000274473 | ENSP00000252252 | multiple EGF-like-domains 10; Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May pl [...] | keratin 6B | 0.542 |
MEGF11 | KRT6B | ENSP00000386908 | ENSP00000252252 | multiple EGF-like-domains 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity) | keratin 6B | 0.542 |
MEGF6 | KRT6B | ENSP00000348982 | ENSP00000252252 | multiple EGF-like-domains 6 | keratin 6B | 0.542 |