| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MTX1 | SAMM50 | ENSP00000357360 | ENSP00000345445 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.999 |
| MTX1 | TIMM22 | ENSP00000357360 | ENSP00000320236 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of inner mitochondrial membrane 22 homolog (yeast); Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity) | 0.411 |
| MTX1 | TOMM20 | ENSP00000357360 | ENSP00000355566 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.984 |
| MTX1 | TOMM22 | ENSP00000357360 | ENSP00000216034 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | 0.976 |
| MTX1 | TOMM40 | ENSP00000357360 | ENSP00000252487 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity) | 0.996 |
| MTX1 | TOMM7 | ENSP00000357360 | ENSP00000351214 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of outer mitochondrial membrane 7 homolog (yeast); Required for assembly and stability of the TOM complex | 0.964 |
| MTX1 | TOMM70A | ENSP00000357360 | ENSP00000284320 | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity) | 0.981 |
| SAMM50 | MTX1 | ENSP00000345445 | ENSP00000357360 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | metaxin 1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) | 0.999 |
| SAMM50 | TIMM17A | ENSP00000345445 | ENSP00000356256 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.504 |
| SAMM50 | TIMM22 | ENSP00000345445 | ENSP00000320236 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of inner mitochondrial membrane 22 homolog (yeast); Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity) | 0.711 |
| SAMM50 | TIMM50 | ENSP00000345445 | ENSP00000318115 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body | 0.569 |
| SAMM50 | TOMM20 | ENSP00000345445 | ENSP00000355566 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.989 |
| SAMM50 | TOMM22 | ENSP00000345445 | ENSP00000216034 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | 0.995 |
| SAMM50 | TOMM40 | ENSP00000345445 | ENSP00000252487 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity) | 0.999 |
| SAMM50 | TOMM7 | ENSP00000345445 | ENSP00000351214 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of outer mitochondrial membrane 7 homolog (yeast); Required for assembly and stability of the TOM complex | 0.977 |
| SAMM50 | TOMM70A | ENSP00000345445 | ENSP00000284320 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity) | 0.976 |
| TIMM17A | SAMM50 | ENSP00000356256 | ENSP00000345445 | translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) | 0.504 |
| TIMM17A | TIMM21 | ENSP00000356256 | ENSP00000169551 | translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | translocase of inner mitochondrial membrane 21 homolog (yeast); Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes | 0.997 |
| TIMM17A | TIMM22 | ENSP00000356256 | ENSP00000320236 | translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | translocase of inner mitochondrial membrane 22 homolog (yeast); Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity) | 0.919 |
| TIMM17A | TIMM50 | ENSP00000356256 | ENSP00000318115 | translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body | 0.997 |
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