ALLC protein (Homo sapiens) - STRING network view

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ALLC

allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals (391 aa)

Predicted Functional Partners:

APP

0.820

MAPK14

0.702

MAPK11

0.653

DPYS

0.637

DPYSL3

0.629

DPYSL4

0.629

CRMP1

0.629

DPYSL2

0.629

DPYSL5

0.629

XDH

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALLC	APP	ENSP00000252505	ENSP00000284981	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	amyloid beta (A4) precursor protein	0.820
ALLC	CRMP1	ENSP00000252505	ENSP00000321606	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	0.629
ALLC	DPYS	ENSP00000252505	ENSP00000276651	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate	0.637
ALLC	DPYSL2	ENSP00000252505	ENSP00000309539	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis	0.629
ALLC	DPYSL3	ENSP00000252505	ENSP00000343690	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)	0.629
ALLC	DPYSL4	ENSP00000252505	ENSP00000339850	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)	0.629
ALLC	DPYSL5	ENSP00000252505	ENSP00000288699	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	0.629
ALLC	MAPK11	ENSP00000252505	ENSP00000333685	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...]	0.653
ALLC	MAPK14	ENSP00000252505	ENSP00000229794	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.702
ALLC	XDH	ENSP00000252505	ENSP00000368727	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro)	0.583
APP	ALLC	ENSP00000284981	ENSP00000252505	amyloid beta (A4) precursor protein	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.820
CRMP1	ALLC	ENSP00000321606	ENSP00000252505	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.629
CRMP1	DPYSL2	ENSP00000321606	ENSP00000309539	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis	0.987
CRMP1	DPYSL3	ENSP00000321606	ENSP00000343690	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	dihydropyrimidinase-like 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)	0.959
CRMP1	DPYSL4	ENSP00000321606	ENSP00000339850	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	dihydropyrimidinase-like 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)	0.909
CRMP1	DPYSL5	ENSP00000321606	ENSP00000288699	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	0.908
DPYS	ALLC	ENSP00000276651	ENSP00000252505	dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.637
DPYS	DPYSL5	ENSP00000276651	ENSP00000288699	dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	0.598
DPYSL2	ALLC	ENSP00000309539	ENSP00000252505	dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.629
DPYSL2	CRMP1	ENSP00000309539	ENSP00000321606	dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	0.987

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