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STRINGSTRING
FANCG FANCG KANSL1 KANSL1 FAM107A FAM107A NSL1 NSL1 USHBP1 USHBP1 USH1C USH1C ABLIM1 ABLIM1 NECAB2 NECAB2 MCCC2 MCCC2 NOC4L NOC4L BTD BTD
"USHBP1" - Usher syndrome 1C binding protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USHBP1Usher syndrome 1C binding protein 1 (703 aa)    
Predicted Functional Partners:
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta) (563 aa)
            score_image   0.888
USH1C
Usher syndrome 1C (autosomal recessive, severe); Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity) (899 aa)
        score_image   score_image   0.859
BTD
biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation (543 aa)
            score_image   0.758
FANCG
Fanconi anemia, complementation group G; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (622 aa)
        score_image       0.718
ABLIM1
actin binding LIM protein 1 (778 aa)
        score_image   score_image   0.655
NSL1
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis (281 aa)
        score_image       0.605
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
        score_image       0.605
KANSL1
KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription (1105 aa)
        score_image       0.605
NECAB2
N-terminal EF-hand calcium binding protein 2 (386 aa)
        score_image       0.595
FAM107A
family with sequence similarity 107, member A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development (144 aa)
        score_image       0.592
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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