node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
G6PD | GNPDA1 | ENSP00000377192 | ENSP00000311876 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | 0.651 |
G6PD | H6PD | ENSP00000377192 | ENSP00000366620 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | 0.957 |
G6PD | PGD | ENSP00000377192 | ENSP00000270776 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) | 0.979 |
G6PD | PGLS | ENSP00000377192 | ENSP00000252603 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate | 0.992 |
G6PD | TALDO1 | ENSP00000377192 | ENSP00000321259 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | transaldolase 1; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) | 0.908 |
G6PD | TKT | ENSP00000377192 | ENSP00000405455 | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.843 |
GLS2 | PGLS | ENSP00000310447 | ENSP00000252603 | glutaminase 2 (liver, mitochondrial); Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate | 0.732 |
GNPDA1 | G6PD | ENSP00000311876 | ENSP00000377192 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | 0.651 |
GNPDA1 | H6PD | ENSP00000311876 | ENSP00000366620 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | 0.903 |
GNPDA1 | PGD | ENSP00000311876 | ENSP00000270776 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) | 0.580 |
GNPDA1 | PGLS | ENSP00000311876 | ENSP00000252603 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate | 0.860 |
GNPDA1 | TALDO1 | ENSP00000311876 | ENSP00000321259 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | transaldolase 1; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) | 0.611 |
GNPDA1 | TKT | ENSP00000311876 | ENSP00000405455 | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.642 |
H6PD | G6PD | ENSP00000366620 | ENSP00000377192 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | glucose-6-phosphate dehydrogenase; Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power | 0.957 |
H6PD | GNPDA1 | ENSP00000366620 | ENSP00000311876 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | glucosamine-6-phosphate deaminase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity) | 0.903 |
H6PD | PGD | ENSP00000366620 | ENSP00000270776 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) | 0.996 |
H6PD | PGLS | ENSP00000366620 | ENSP00000252603 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate | 0.960 |
H6PD | SDHB | ENSP00000366620 | ENSP00000364649 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.455 |
H6PD | SDHC | ENSP00000366620 | ENSP00000356953 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.406 |
H6PD | TALDO1 | ENSP00000366620 | ENSP00000321259 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates | transaldolase 1; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) | 0.944 |