| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPS15 | FCHO1 | ENSP00000360798 | ENSP00000252771 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.770 |
| EPS15 | TRIP10 | ENSP00000360798 | ENSP00000320493 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | thyroid hormone receptor interactor 10 | 0.483 |
| FCHO1 | EPS15 | ENSP00000252771 | ENSP00000360798 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.770 |
| FCHO1 | HAS1 | ENSP00000252771 | ENSP00000222115 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate | 0.741 |
| FCHO1 | HAS2 | ENSP00000252771 | ENSP00000306991 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.741 |
| FCHO1 | HAS3 | ENSP00000252771 | ENSP00000304440 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.741 |
| FCHO1 | KY | ENSP00000252771 | ENSP00000397598 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | 0.822 |
| FCHO1 | MYH11 | ENSP00000252771 | ENSP00000379616 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | myosin, heavy chain 11, smooth muscle; Muscle contraction | 0.708 |
| FCHO1 | MYH8 | ENSP00000252771 | ENSP00000384330 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.708 |
| FCHO1 | MYO18A | ENSP00000252771 | ENSP00000437073 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | myosin XVIIIA; May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration | 0.708 |
| FCHO1 | MYO5A | ENSP00000252771 | ENSP00000382177 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.710 |
| FCHO1 | TRIP10 | ENSP00000252771 | ENSP00000320493 | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | thyroid hormone receptor interactor 10 | 0.835 |
| HAS1 | FCHO1 | ENSP00000222115 | ENSP00000252771 | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.741 |
| HAS2 | FCHO1 | ENSP00000306991 | ENSP00000252771 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.741 |
| HAS2 | HAS3 | ENSP00000306991 | ENSP00000304440 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.587 |
| HAS3 | FCHO1 | ENSP00000304440 | ENSP00000252771 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.741 |
| HAS3 | HAS2 | ENSP00000304440 | ENSP00000306991 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.587 |
| KY | FCHO1 | ENSP00000397598 | ENSP00000252771 | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | FCH domain only 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors | 0.822 |
| KY | MYH11 | ENSP00000397598 | ENSP00000379616 | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | myosin, heavy chain 11, smooth muscle; Muscle contraction | 0.429 |
| KY | MYH8 | ENSP00000397598 | ENSP00000384330 | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.429 |
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