node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC60 | CNEP1R1 | ENSP00000333374 | ENSP00000405635 | coiled-coil domain containing 60 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | 0.509 |
CCDC60 | PHLDB3 | ENSP00000333374 | ENSP00000292140 | coiled-coil domain containing 60 | pleckstrin homology-like domain, family B, member 3 | 0.566 |
CCDC60 | SPINK8 | ENSP00000333374 | ENSP00000407497 | coiled-coil domain containing 60 | serine peptidase inhibitor, Kazal type 8 (putative); Probable serine protease inhibitor (By similarity) | 0.561 |
CCDC60 | ZNF764 | ENSP00000333374 | ENSP00000252797 | coiled-coil domain containing 60 | zinc finger protein 764; May be involved in transcriptional regulation | 0.507 |
CNEP1R1 | CCDC60 | ENSP00000405635 | ENSP00000333374 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | coiled-coil domain containing 60 | 0.509 |
CNEP1R1 | PHLDB3 | ENSP00000405635 | ENSP00000292140 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | pleckstrin homology-like domain, family B, member 3 | 0.568 |
CNEP1R1 | SPINK8 | ENSP00000405635 | ENSP00000407497 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | serine peptidase inhibitor, Kazal type 8 (putative); Probable serine protease inhibitor (By similarity) | 0.563 |
CNEP1R1 | ZNF764 | ENSP00000405635 | ENSP00000252797 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | zinc finger protein 764; May be involved in transcriptional regulation | 0.509 |
FBXL19 | ZNF764 | ENSP00000369666 | ENSP00000252797 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 764; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF764 | ENSP00000432786 | ENSP00000252797 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 764; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF764 | ENSP00000366271 | ENSP00000252797 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 764; May be involved in transcriptional regulation | 0.501 |
KRTAP4-12 | PLSCR1 | ENSP00000377582 | ENSP00000345494 | keratin associated protein 4-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | 0.516 |
KRTAP4-12 | ZNF764 | ENSP00000377582 | ENSP00000252797 | keratin associated protein 4-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | zinc finger protein 764; May be involved in transcriptional regulation | 0.680 |
PHLDB3 | CCDC60 | ENSP00000292140 | ENSP00000333374 | pleckstrin homology-like domain, family B, member 3 | coiled-coil domain containing 60 | 0.566 |
PHLDB3 | CNEP1R1 | ENSP00000292140 | ENSP00000405635 | pleckstrin homology-like domain, family B, member 3 | CTD nuclear envelope phosphatase 1 regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid [...] | 0.568 |
PHLDB3 | SPINK8 | ENSP00000292140 | ENSP00000407497 | pleckstrin homology-like domain, family B, member 3 | serine peptidase inhibitor, Kazal type 8 (putative); Probable serine protease inhibitor (By similarity) | 0.583 |
PHLDB3 | ZNF764 | ENSP00000292140 | ENSP00000252797 | pleckstrin homology-like domain, family B, member 3 | zinc finger protein 764; May be involved in transcriptional regulation | 0.566 |
PLSCR1 | KRTAP4-12 | ENSP00000345494 | ENSP00000377582 | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | keratin associated protein 4-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.516 |
PLSCR1 | ZNF764 | ENSP00000345494 | ENSP00000252797 | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | zinc finger protein 764; May be involved in transcriptional regulation | 0.556 |
SPINK8 | CCDC60 | ENSP00000407497 | ENSP00000333374 | serine peptidase inhibitor, Kazal type 8 (putative); Probable serine protease inhibitor (By similarity) | coiled-coil domain containing 60 | 0.561 |