node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2A2 | HRC | ENSP00000440045 | ENSP00000252825 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.846 |
ATP2A2 | TRDN | ENSP00000440045 | ENSP00000381240 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle | triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) | 0.437 |
HRC | ATP2A2 | ENSP00000252825 | ENSP00000440045 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle | 0.846 |
HRC | KLK4 | ENSP00000252825 | ENSP00000326159 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | kallikrein-related peptidase 4; Involved in enamel formation | 0.452 |
HRC | NLRP6 | ENSP00000252825 | ENSP00000309767 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.590 |
HRC | RASSF7 | ENSP00000252825 | ENSP00000344226 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization | 0.653 |
HRC | RNH1 | ENSP00000252825 | ENSP00000346402 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis | 0.680 |
HRC | SULT2A1 | ENSP00000252825 | ENSP00000222002 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands | 0.657 |
HRC | TRDN | ENSP00000252825 | ENSP00000381240 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) | 0.977 |
HRC | USP30 | ENSP00000252825 | ENSP00000257548 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology | 0.519 |
HRC | WAC | ENSP00000252825 | ENSP00000346986 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | WW domain containing adaptor with coiled-coil | 0.416 |
KLK4 | HRC | ENSP00000326159 | ENSP00000252825 | kallikrein-related peptidase 4; Involved in enamel formation | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.452 |
KLK4 | SULT2A1 | ENSP00000326159 | ENSP00000222002 | kallikrein-related peptidase 4; Involved in enamel formation | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands | 0.560 |
NLRP6 | HRC | ENSP00000309767 | ENSP00000252825 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.590 |
RASSF7 | HRC | ENSP00000344226 | ENSP00000252825 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.653 |
RNH1 | HRC | ENSP00000346402 | ENSP00000252825 | ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.680 |
SULT2A1 | HRC | ENSP00000222002 | ENSP00000252825 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.657 |
SULT2A1 | KLK4 | ENSP00000222002 | ENSP00000326159 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands | kallikrein-related peptidase 4; Involved in enamel formation | 0.560 |
TRDN | ATP2A2 | ENSP00000381240 | ENSP00000440045 | triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle | 0.437 |
TRDN | HRC | ENSP00000381240 | ENSP00000252825 | triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.977 |