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STRINGSTRING
TRDN TRDN ATP2A2 ATP2A2 USP30 USP30 WAC WAC RNH1 RNH1 HRC HRC NLRP6 NLRP6 RASSF7 RASSF7 SULT2A1 SULT2A1 KLK4 KLK4
"HRC" - histidine rich calcium binding protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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protein homology
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Score
HRChistidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle (699 aa)    
Predicted Functional Partners:
TRDN
triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) (729 aa)
      score_image score_image   score_image   0.977
ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (1042 aa)
            score_image   0.846
RNH1
ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (461 aa)
            score_image   0.680
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (285 aa)
            score_image   0.657
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (373 aa)
            score_image   0.653
NLRP6
NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] (892 aa)
            score_image   0.590
USP30
ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology (517 aa)
            score_image   0.519
KLK4
kallikrein-related peptidase 4; Involved in enamel formation (254 aa)
            score_image   0.452
WAC
WW domain containing adaptor with coiled-coil (647 aa)
            score_image   0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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