ATXN10 protein (Homo sapiens) - STRING network view

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ATXN10

ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity) (475 aa)

Predicted Functional Partners:

UBC

0.984

ANO10

0.910

PPP2R2B

0.820

PLK1

0.815

C10orf2

0.812

ATXN7

0.756

PSMD11

0.755

PLEKHG4

0.751

SPTBN2

0.741

ATXN3

0.700

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO10	ATXN10	ENSP00000292246	ENSP00000252934	anoctamin 10	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	0.910
ANO10	UBC	ENSP00000292246	ENSP00000344818	anoctamin 10	ubiquitin C	0.890
ATXN10	ANO10	ENSP00000252934	ENSP00000292246	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	anoctamin 10	0.910
ATXN10	ATXN3	ENSP00000252934	ENSP00000376965	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	ataxin 3	0.700
ATXN10	ATXN7	ENSP00000252934	ENSP00000381590	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization	0.756
ATXN10	C10orf2	ENSP00000252934	ENSP00000309595	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals	0.812
ATXN10	PLEKHG4	ENSP00000252934	ENSP00000353646	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi	0.751
ATXN10	PLK1	ENSP00000252934	ENSP00000300093	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...]	0.815
ATXN10	PPP2R2B	ENSP00000252934	ENSP00000336591	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	protein phosphatase 2, regulatory subunit B, beta	0.820
ATXN10	PSMD11	ENSP00000252934	ENSP00000261712	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs)- its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity	0.755
ATXN10	SPTBN2	ENSP00000252934	ENSP00000311489	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton	0.741
ATXN10	UBC	ENSP00000252934	ENSP00000344818	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	ubiquitin C	0.984
ATXN3	ATXN10	ENSP00000376965	ENSP00000252934	ataxin 3	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	0.700
ATXN3	ATXN7	ENSP00000376965	ENSP00000381590	ataxin 3	ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization	0.881
ATXN3	C10orf2	ENSP00000376965	ENSP00000309595	ataxin 3	chromosome 10 open reading frame 2; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals	0.720
ATXN3	PLEKHG4	ENSP00000376965	ENSP00000353646	ataxin 3	pleckstrin homology domain containing, family G (with RhoGef domain) member 4; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi	0.720
ATXN3	PPP2R2B	ENSP00000376965	ENSP00000336591	ataxin 3	protein phosphatase 2, regulatory subunit B, beta	0.720
ATXN3	SPTBN2	ENSP00000376965	ENSP00000311489	ataxin 3	spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton	0.580
ATXN3	UBC	ENSP00000376965	ENSP00000344818	ataxin 3	ubiquitin C	0.999
ATXN7	ATXN10	ENSP00000381590	ENSP00000252934	ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization	ataxin 10; Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis (By similarity)	0.756

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