| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CALY | DLG1 | ENSP00000252939 | ENSP00000345731 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | discs, large homolog 1 (Drosophila) | 0.669 |
| CALY | DLG2 | ENSP00000252939 | ENSP00000365272 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.669 |
| CALY | DLG3 | ENSP00000252939 | ENSP00000363480 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.669 |
| CALY | DLG4 | ENSP00000252939 | ENSP00000293813 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.703 |
| CALY | DRD1 | ENSP00000252939 | ENSP00000327652 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | 0.927 |
| CALY | DRD5 | ENSP00000252939 | ENSP00000306129 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase | 0.712 |
| CALY | LGALS4 | ENSP00000252939 | ENSP00000302100 | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | lectin, galactoside-binding, soluble, 4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions | 0.665 |
| DLG1 | CALY | ENSP00000345731 | ENSP00000252939 | discs, large homolog 1 (Drosophila) | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | 0.669 |
| DLG1 | DLG2 | ENSP00000345731 | ENSP00000365272 | discs, large homolog 1 (Drosophila) | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.574 |
| DLG1 | DLG3 | ENSP00000345731 | ENSP00000363480 | discs, large homolog 1 (Drosophila) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.955 |
| DLG1 | DLG4 | ENSP00000345731 | ENSP00000293813 | discs, large homolog 1 (Drosophila) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
| DLG2 | CALY | ENSP00000365272 | ENSP00000252939 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | 0.669 |
| DLG2 | DLG1 | ENSP00000365272 | ENSP00000345731 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | discs, large homolog 1 (Drosophila) | 0.574 |
| DLG2 | DLG4 | ENSP00000365272 | ENSP00000293813 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.585 |
| DLG3 | CALY | ENSP00000363480 | ENSP00000252939 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | 0.669 |
| DLG3 | DLG1 | ENSP00000363480 | ENSP00000345731 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 1 (Drosophila) | 0.955 |
| DLG3 | DLG4 | ENSP00000363480 | ENSP00000293813 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
| DLG4 | CALY | ENSP00000293813 | ENSP00000252939 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | calcyon neuron-specific vesicular protein; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis | 0.703 |
| DLG4 | DLG1 | ENSP00000293813 | ENSP00000345731 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large homolog 1 (Drosophila) | 0.956 |
| DLG4 | DLG2 | ENSP00000293813 | ENSP00000365272 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.585 |
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