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PTGS2 PTGS2 ADH4 ADH4 UGT1A7 UGT1A7 CYP2E1 CYP2E1 UGT1A10 UGT1A10 GSTP1 GSTP1 UGT1A1 UGT1A1 GSTM1 GSTM1 EPHX1 EPHX1 ADH1B ADH1B GSTT1 GSTT1
"CYP2E1" - cytochrome P450, family 2, subfamily E, polypeptide 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Predicted Interactions
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protein homology
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CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms (493 aa)    
Predicted Functional Partners:
GSTM1
glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa)
          score_image score_image   0.981
GSTT1
glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide (240 aa)
          score_image score_image   0.981
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity (604 aa)
          score_image score_image   0.980
GSTP1
glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (210 aa)
          score_image score_image   0.974
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
      score_image   score_image score_image   0.972
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone (533 aa)
          score_image score_image   0.970
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (530 aa)
          score_image score_image   0.964
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic) (455 aa)
        score_image score_image score_image   0.963
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa)
          score_image score_image   0.963
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (530 aa)
          score_image score_image   0.961
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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