node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH1B | CYP2E1 | ENSP00000306606 | ENSP00000252945 | alcohol dehydrogenase 1B (class I), beta polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.972 |
ADH1B | GSTM1 | ENSP00000306606 | ENSP00000311469 | alcohol dehydrogenase 1B (class I), beta polypeptide | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.954 |
ADH1B | GSTP1 | ENSP00000306606 | ENSP00000381607 | alcohol dehydrogenase 1B (class I), beta polypeptide | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.942 |
ADH1B | GSTT1 | ENSP00000306606 | ENSP00000248935 | alcohol dehydrogenase 1B (class I), beta polypeptide | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.950 |
ADH1B | UGT1A1 | ENSP00000306606 | ENSP00000304845 | alcohol dehydrogenase 1B (class I), beta polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.908 |
ADH1B | UGT1A10 | ENSP00000306606 | ENSP00000343838 | alcohol dehydrogenase 1B (class I), beta polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.902 |
ADH1B | UGT1A7 | ENSP00000306606 | ENSP00000362525 | alcohol dehydrogenase 1B (class I), beta polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.905 |
ADH4 | CYP2E1 | ENSP00000265512 | ENSP00000252945 | alcohol dehydrogenase 4 (class II), pi polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.963 |
ADH4 | GSTM1 | ENSP00000265512 | ENSP00000311469 | alcohol dehydrogenase 4 (class II), pi polypeptide | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.939 |
ADH4 | GSTP1 | ENSP00000265512 | ENSP00000381607 | alcohol dehydrogenase 4 (class II), pi polypeptide | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.921 |
ADH4 | GSTT1 | ENSP00000265512 | ENSP00000248935 | alcohol dehydrogenase 4 (class II), pi polypeptide | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.930 |
ADH4 | UGT1A1 | ENSP00000265512 | ENSP00000304845 | alcohol dehydrogenase 4 (class II), pi polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.906 |
ADH4 | UGT1A10 | ENSP00000265512 | ENSP00000343838 | alcohol dehydrogenase 4 (class II), pi polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.900 |
ADH4 | UGT1A7 | ENSP00000265512 | ENSP00000362525 | alcohol dehydrogenase 4 (class II), pi polypeptide | UDP glucuronosyltransferase 1 family, polypeptide A7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds | 0.900 |
CYP2E1 | ADH1B | ENSP00000252945 | ENSP00000306606 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.972 |
CYP2E1 | ADH4 | ENSP00000252945 | ENSP00000265512 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.963 |
CYP2E1 | EPHX1 | ENSP00000252945 | ENSP00000272167 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | epoxide hydrolase 1, microsomal (xenobiotic) | 0.963 |
CYP2E1 | GSTM1 | ENSP00000252945 | ENSP00000311469 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.981 |
CYP2E1 | GSTP1 | ENSP00000252945 | ENSP00000381607 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.974 |
CYP2E1 | GSTT1 | ENSP00000252945 | ENSP00000248935 | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.981 |