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STRINGSTRING
IQCC IQCC KEAP1 KEAP1 KBTBD7 KBTBD7 TMEM160 TMEM160 CARK CARK GNPDA2 GNPDA2 TMEM18 TMEM18 POC5 POC5 MTIF3 MTIF3 TNNI3K TNNI3K SEC16B SEC16B
"TMEM160" - transmembrane protein 160 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TMEM160transmembrane protein 160 (188 aa)    
Predicted Functional Partners:
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
        score_image       0.740
KBTBD7
kelch repeat and BTB (POZ) domain containing 7 (684 aa)
        score_image       0.692
POC5
POC5 centriolar protein homolog (Chlamydomonas); Essential for the assembly of the distal half of centrioles, required for centriole elongation (575 aa)
            score_image   0.658
CARK
FPGT-TNNI3K readthrough; May play a role in cardiac physiology (936 aa)
            score_image   0.581
MTIF3
mitochondrial translational initiation factor 3; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins (278 aa)
            score_image   0.569
TNNI3K
TNNI3 interacting kinase; May play a role in cardiac physiology (936 aa)
            score_image   0.567
IQCC
IQ motif containing C (546 aa)
            score_image   0.564
SEC16B
SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization (1060 aa)
            score_image   0.562
TMEM18
transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (140 aa)
            score_image   0.535
GNPDA2
glucosamine-6-phosphate deaminase 2 (276 aa)
            score_image   0.508
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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