node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | CTTN | ENSP00000355645 | ENSP00000365745 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | 0.982 |
ACTA1 | DBNL | ENSP00000355645 | ENSP00000417653 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | 0.888 |
ACTA1 | HIP1R | ENSP00000355645 | ENSP00000253083 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis | 0.928 |
ACTA1 | UBC | ENSP00000355645 | ENSP00000344818 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | ubiquitin C | 0.999 |
CLTA | CLTB | ENSP00000242285 | ENSP00000309415 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.903 |
CLTA | EPN1 | ENSP00000242285 | ENSP00000406209 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | 0.958 |
CLTA | EPS15 | ENSP00000242285 | ENSP00000360798 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.969 |
CLTA | GAK | ENSP00000242285 | ENSP00000314499 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.953 |
CLTA | HIP1R | ENSP00000242285 | ENSP00000253083 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis | 0.917 |
CLTA | SNAP91 | ENSP00000242285 | ENSP00000358708 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | synaptosomal-associated protein, 91kDa homolog (mouse); Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity) | 0.574 |
CLTA | UBC | ENSP00000242285 | ENSP00000344818 | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ubiquitin C | 0.811 |
CLTB | CLTA | ENSP00000309415 | ENSP00000242285 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.903 |
CLTB | EPN1 | ENSP00000309415 | ENSP00000406209 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | 0.631 |
CLTB | EPS15 | ENSP00000309415 | ENSP00000360798 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.813 |
CLTB | GAK | ENSP00000309415 | ENSP00000314499 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.955 |
CLTB | HIP1R | ENSP00000309415 | ENSP00000253083 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis | 0.985 |
CLTB | SNAP91 | ENSP00000309415 | ENSP00000358708 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | synaptosomal-associated protein, 91kDa homolog (mouse); Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity) | 0.689 |
CLTB | UBC | ENSP00000309415 | ENSP00000344818 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ubiquitin C | 0.755 |
CTTN | ACTA1 | ENSP00000365745 | ENSP00000355645 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.982 |
CTTN | HIP1R | ENSP00000365745 | ENSP00000253083 | cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis | 0.984 |