node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACPP | CHRAC1 | ENSP00000323036 | ENSP00000220913 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | 0.609 |
ACPP | MMP20 | ENSP00000323036 | ENSP00000260228 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation | 0.451 |
ACPP | ZNF331 | ENSP00000323036 | ENSP00000253144 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.602 |
CCDC86 | DHCR24 | ENSP00000227520 | ENSP00000360316 | coiled-coil domain containing 86 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | 0.489 |
CCDC86 | ZNF331 | ENSP00000227520 | ENSP00000253144 | coiled-coil domain containing 86 | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.721 |
CHRAC1 | ACPP | ENSP00000220913 | ENSP00000323036 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.609 |
CHRAC1 | MMP20 | ENSP00000220913 | ENSP00000260228 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation | 0.497 |
CHRAC1 | ZNF331 | ENSP00000220913 | ENSP00000253144 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.657 |
DHCR24 | CCDC86 | ENSP00000360316 | ENSP00000227520 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | coiled-coil domain containing 86 | 0.489 |
DHCR24 | ZNF331 | ENSP00000360316 | ENSP00000253144 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.478 |
DPRX | ZNF331 | ENSP00000365838 | ENSP00000253144 | divergent-paired related homeobox; Putative transcription factor (By similarity) | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.556 |
FBXL19 | ZNF331 | ENSP00000369666 | ENSP00000253144 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.501 |
KDM2A | ZNF331 | ENSP00000432786 | ENSP00000253144 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.501 |
KDM2B | ZNF331 | ENSP00000366271 | ENSP00000253144 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.501 |
MMP20 | ACPP | ENSP00000260228 | ENSP00000323036 | matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.451 |
MMP20 | CHRAC1 | ENSP00000260228 | ENSP00000220913 | matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | 0.497 |
MMP20 | ZNF331 | ENSP00000260228 | ENSP00000253144 | matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.506 |
XRN1 | ZNF331 | ENSP00000264951 | ENSP00000253144 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | 0.543 |
ZNF331 | ACPP | ENSP00000253144 | ENSP00000323036 | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | acid phosphatase, prostate; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma | 0.602 |
ZNF331 | CCDC86 | ENSP00000253144 | ENSP00000227520 | zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis | coiled-coil domain containing 86 | 0.721 |