GRWD1 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

GRWD1

glutamate-rich WD repeat containing 1 (446 aa)

Predicted Functional Partners:

BOP1

0.995

PES1

0.986

BRIX1

0.984

PWP1

0.979

TWISTNB

0.974

ENSG00000204775

0.971

RPL3

0.970

NOP2

0.969

WDR12

0.966

MRTO4

0.958

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	BRIX1	ENSP00000304151	ENSP00000338862	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.989
BOP1	GRWD1	ENSP00000304151	ENSP00000253237	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	glutamate-rich WD repeat containing 1	0.995
BOP1	MRTO4	ENSP00000304151	ENSP00000364320	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity)	0.982
BOP1	NOP2	ENSP00000304151	ENSP00000382392	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.996
BOP1	PES1	ENSP00000304151	ENSP00000346725	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.999
BOP1	PWP1	ENSP00000304151	ENSP00000387365	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	PWP1 homolog (S. cerevisiae); May play an important role in cell growth and/or transcription	0.939
BOP1	RPL3	ENSP00000304151	ENSP00000346001	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes	0.513
BOP1	TWISTNB	ENSP00000304151	ENSP00000222567	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	TWIST neighbor; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters	0.761
BOP1	WDR12	ENSP00000304151	ENSP00000261015	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.999
BRIX1	BOP1	ENSP00000338862	ENSP00000304151	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.989
BRIX1	ENSG00000204775	ENSP00000338862	ENSP00000366629	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	KM-PA-2 protein; Uncharacterized protein	0.989
BRIX1	GRWD1	ENSP00000338862	ENSP00000253237	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	glutamate-rich WD repeat containing 1	0.984
BRIX1	MRTO4	ENSP00000338862	ENSP00000364320	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity)	0.994
BRIX1	NOP2	ENSP00000338862	ENSP00000382392	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.994
BRIX1	PES1	ENSP00000338862	ENSP00000346725	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.994
BRIX1	PWP1	ENSP00000338862	ENSP00000387365	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	PWP1 homolog (S. cerevisiae); May play an important role in cell growth and/or transcription	0.994
BRIX1	RPL3	ENSP00000338862	ENSP00000346001	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes	0.772
BRIX1	TWISTNB	ENSP00000338862	ENSP00000222567	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	TWIST neighbor; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters	0.915
BRIX1	WDR12	ENSP00000338862	ENSP00000261015	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.998
ENSG00000204775	BRIX1	ENSP00000366629	ENSP00000338862	KM-PA-2 protein; Uncharacterized protein	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.989

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