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STRINGSTRING
WDR36 WDR36 WDR43 WDR43 WDR75 WDR75 UTP15 UTP15 WDR12 WDR12 CIRH1A CIRH1A HEATR1 HEATR1 NOP14 NOP14 NOL11 NOL11 NOL12 NOL12 LRRC37A3 LRRC37A3
"NOL11" - nucleolar protein 11 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOL11nucleolar protein 11 (719 aa)    
Predicted Functional Partners:
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
      score_image   score_image score_image   0.978
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa)
      score_image     score_image   0.788
WDR43
WD repeat domain 43 (677 aa)
      score_image     score_image   0.782
WDR36
WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa)
      score_image     score_image   0.745
NOL12
nucleolar protein 12; May bind to 28S rRNA (By similarity) (213 aa)
            score_image   0.726
NOP14
NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) (857 aa)
      score_image     score_image   0.726
LRRC37A3
leucine rich repeat containing 37, member A3 (1634 aa)
            score_image   0.658
HEATR1
HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2144 aa)
      score_image     score_image   0.553
WDR75
WD repeat domain 75 (830 aa)
      score_image     score_image   0.524
WDR12
WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
      score_image         0.510
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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