Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | BPIFB1 | BPI fold containing family B, member 1 (484 aa) | ||||||||||||
Predicted Functional Partners:
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 | BPIFB3 | BPI fold containing family B, member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity) (476 aa) |
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0.864 | ||||||||||
 | BPIFB2 | BPI fold containing family B, member 2 (458 aa) |
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0.864 | ||||||||||
 | BPIFA2 | BPI fold containing family A, member 2 (249 aa) |
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0.814 | ||||||||||
 | SAMD4B | sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (694 aa) |
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0.748 | ||||||||||
 | KCNRG | potassium channel regulator; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (272 aa) |
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0.548 | ||||||||||
 | GPR137C | G protein-coupled receptor 137C (429 aa) |
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0.499 | ||||||||||
 | SAMD4A | sterile alpha motif domain containing 4A; Acts as a translational repressor of SRE-containing messengers (717 aa) |
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0.485 | ||||||||||
 | SMGA | Protein Smaug homolog 1 (629 aa) |
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0.485 | ||||||||||
 | BPI | bactericidal/permeability-increasing protein (487 aa) |
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0.459 | ||||||||||
 | C6orf58 | chromosome 6 open reading frame 58 (330 aa) |
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0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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