node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF9 | C1orf192 | ENSP00000253401 | ENSP00000356951 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | chromosome 1 open reading frame 192 | 0.452 |
ARHGEF9 | CHIC1 | ENSP00000253401 | ENSP00000362601 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | cysteine-rich hydrophobic domain 1 | 0.543 |
ARHGEF9 | CLASRP | ENSP00000253401 | ENSP00000221455 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity) | 0.490 |
ARHGEF9 | CLCN5 | ENSP00000253401 | ENSP00000365256 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | 0.475 |
ARHGEF9 | FZR1 | ENSP00000253401 | ENSP00000378529 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.443 |
ARHGEF9 | GABRG2 | ENSP00000253401 | ENSP00000410732 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | 0.473 |
ARHGEF9 | GPHN | ENSP00000253401 | ENSP00000417901 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | 0.914 |
ARHGEF9 | SMURF1 | ENSP00000253401 | ENSP00000354621 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.576 |
ARHGEF9 | VPS29 | ENSP00000253401 | ENSP00000380795 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | vacuolar protein sorting 29 homolog (S. cerevisiae); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) | 0.502 |
ARHGEF9 | YLPM1 | ENSP00000253401 | ENSP00000324463 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | YLP motif-containing protein 1 ; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation (By similarity) | 0.551 |
C1orf192 | ARHGEF9 | ENSP00000356951 | ENSP00000253401 | chromosome 1 open reading frame 192 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.452 |
CHIC1 | ARHGEF9 | ENSP00000362601 | ENSP00000253401 | cysteine-rich hydrophobic domain 1 | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.543 |
CHIC1 | FZR1 | ENSP00000362601 | ENSP00000378529 | cysteine-rich hydrophobic domain 1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.433 |
CLASRP | ARHGEF9 | ENSP00000221455 | ENSP00000253401 | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity) | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.490 |
CLASRP | GPHN | ENSP00000221455 | ENSP00000417901 | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity) | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | 0.757 |
CLCN5 | ARHGEF9 | ENSP00000365256 | ENSP00000253401 | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.475 |
FZR1 | ARHGEF9 | ENSP00000378529 | ENSP00000253401 | fizzy/cell division cycle 20 related 1 (Drosophila) | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.443 |
FZR1 | CHIC1 | ENSP00000378529 | ENSP00000362601 | fizzy/cell division cycle 20 related 1 (Drosophila) | cysteine-rich hydrophobic domain 1 | 0.433 |
FZR1 | SMURF1 | ENSP00000378529 | ENSP00000354621 | fizzy/cell division cycle 20 related 1 (Drosophila) | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.587 |
GABRG2 | ARHGEF9 | ENSP00000410732 | ENSP00000253401 | gamma-aminobutyric acid (GABA) A receptor, gamma 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | Cdc42 guanine nucleotide exchange factor (GEF) 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters | 0.473 |