PDLIM4 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Known Interactions

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PDLIM4

PDZ and LIM domain 4 (330 aa)

Predicted Functional Partners:

PTPN13

0.863

GABRB1

0.753

TRIP6

0.748

SPTAN1

0.586

ABCA1

0.584

PHB2

0.569

HSP90AA1

0.531

PRDM10

0.524

HSP90AB1

0.507

EPM2A

0.501

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	PDLIM4	ENSP00000363868	ENSP00000253754	ATP-binding cassette, sub-family A (ABC1), member 1	PDZ and LIM domain 4	0.584
ABCA1	PRDM10	ENSP00000363868	ENSP00000351686	ATP-binding cassette, sub-family A (ABC1), member 1	PR domain containing 10	0.472
EPM2A	PDLIM4	ENSP00000356489	ENSP00000253754	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	PDZ and LIM domain 4	0.501
EPM2A	PHB2	ENSP00000356489	ENSP00000441875	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging	0.580
EPM2A	SPTAN1	ENSP00000356489	ENSP00000361824	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	spectrin, alpha, non-erythrocytic 1	0.580
GABRB1	PDLIM4	ENSP00000295454	ENSP00000253754	gamma-aminobutyric acid (GABA) A receptor, beta 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	PDZ and LIM domain 4	0.753
HSP90AA1	HSP90AB1	ENSP00000335153	ENSP00000325875	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.999
HSP90AA1	PDLIM4	ENSP00000335153	ENSP00000253754	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	PDZ and LIM domain 4	0.531
HSP90AA1	PRDM10	ENSP00000335153	ENSP00000351686	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	PR domain containing 10	0.729
HSP90AB1	HSP90AA1	ENSP00000325875	ENSP00000335153	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.999
HSP90AB1	PDLIM4	ENSP00000325875	ENSP00000253754	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	PDZ and LIM domain 4	0.507
PDLIM4	ABCA1	ENSP00000253754	ENSP00000363868	PDZ and LIM domain 4	ATP-binding cassette, sub-family A (ABC1), member 1	0.584
PDLIM4	EPM2A	ENSP00000253754	ENSP00000356489	PDZ and LIM domain 4	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.501
PDLIM4	GABRB1	ENSP00000253754	ENSP00000295454	PDZ and LIM domain 4	gamma-aminobutyric acid (GABA) A receptor, beta 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.753
PDLIM4	HSP90AA1	ENSP00000253754	ENSP00000335153	PDZ and LIM domain 4	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.531
PDLIM4	HSP90AB1	ENSP00000253754	ENSP00000325875	PDZ and LIM domain 4	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.507
PDLIM4	PHB2	ENSP00000253754	ENSP00000441875	PDZ and LIM domain 4	prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging	0.569
PDLIM4	PRDM10	ENSP00000253754	ENSP00000351686	PDZ and LIM domain 4	PR domain containing 10	0.524
PDLIM4	PTPN13	ENSP00000253754	ENSP00000394794	PDZ and LIM domain 4	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.863
PDLIM4	SPTAN1	ENSP00000253754	ENSP00000361824	PDZ and LIM domain 4	spectrin, alpha, non-erythrocytic 1	0.586

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