| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6C | GFPT2 | ENSP00000455561 | ENSP00000253778 | Uncharacterized protein | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.913 |
| ATP6C | HK1 | ENSP00000455561 | ENSP00000384774 | Uncharacterized protein | hexokinase 1 | 0.900 |
| ATP6C | HK3 | ENSP00000455561 | ENSP00000292432 | Uncharacterized protein | hexokinase 3 (white cell) | 0.900 |
| ATP6C | HKDC1 | ENSP00000455561 | ENSP00000346643 | Uncharacterized protein | hexokinase domain containing 1 | 0.900 |
| CAD | GFPT2 | ENSP00000264705 | ENSP00000253778 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.990 |
| CAD | GLS | ENSP00000264705 | ENSP00000317379 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.944 |
| CAD | GLUL | ENSP00000264705 | ENSP00000307900 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.969 |
| CAD | HK1 | ENSP00000264705 | ENSP00000384774 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | hexokinase 1 | 0.502 |
| CAD | HK3 | ENSP00000264705 | ENSP00000292432 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | hexokinase 3 (white cell) | 0.502 |
| CAD | HKDC1 | ENSP00000264705 | ENSP00000346643 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | hexokinase domain containing 1 | 0.502 |
| CAD | PPAT | ENSP00000264705 | ENSP00000264220 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | phosphoribosyl pyrophosphate amidotransferase | 0.993 |
| GFPT2 | ATP6C | ENSP00000253778 | ENSP00000455561 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | Uncharacterized protein | 0.913 |
| GFPT2 | CAD | ENSP00000253778 | ENSP00000264705 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.990 |
| GFPT2 | GLS | ENSP00000253778 | ENSP00000317379 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.912 |
| GFPT2 | GLUL | ENSP00000253778 | ENSP00000307900 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.933 |
| GFPT2 | GNPNAT1 | ENSP00000253778 | ENSP00000216410 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glucosamine-phosphate N-acetyltransferase 1 | 0.956 |
| GFPT2 | GPI | ENSP00000253778 | ENSP00000405573 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.907 |
| GFPT2 | HK1 | ENSP00000253778 | ENSP00000384774 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | hexokinase 1 | 0.903 |
| GFPT2 | HK3 | ENSP00000253778 | ENSP00000292432 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | hexokinase 3 (white cell) | 0.903 |
| GFPT2 | HKDC1 | ENSP00000253778 | ENSP00000346643 | glutamine-fructose-6-phosphate transaminase 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | hexokinase domain containing 1 | 0.903 |
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