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STRINGSTRING
OGDHL OGDHL LDHA LDHA SUCLG2 SUCLG2 ACLY ACLY LDHB LDHB OGDH OGDH SDHB SDHB ACACA ACACA SUCLA2 SUCLA2 MDH2 MDH2 DHTKD1 DHTKD1
"ACLY" - ATP citrate lyase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ACLYATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)    
Predicted Functional Partners:
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (1023 aa)
score_image     score_image     score_image   0.996
OGDHL
oxoglutarate dehydrogenase-like (1010 aa)
score_image     score_image     score_image   0.996
DHTKD1
dehydrogenase E1 and transketolase domain containing 1; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) (919 aa)
score_image     score_image     score_image   0.995
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) (463 aa)
score_image   score_image score_image score_image   score_image   0.987
SUCLG2
succinate-CoA ligase, GDP-forming, beta subunit; Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) (440 aa)
score_image   score_image score_image score_image   score_image   0.985
LDHA
lactate dehydrogenase A (361 aa)
score_image     score_image score_image   score_image   0.983
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
score_image     score_image score_image   score_image   0.983
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (280 aa)
score_image     score_image     score_image   0.981
MDH2
malate dehydrogenase 2, NAD (mitochondrial) (338 aa)
score_image     score_image score_image   score_image   0.978
LDHB
lactate dehydrogenase B (334 aa)
score_image     score_image score_image   score_image   0.978
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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