WDR44 protein (Homo sapiens) - STRING network view

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Score

WDR44

WD repeat domain 44 (913 aa)

Predicted Functional Partners:

LSM7

0.970

LSM4

0.906

UBC

0.825

RAB11A

0.794

ILF2

0.644

GRB2

0.635

GPR173

0.633

SLC7A14

0.628

MPZL2

0.622

RWDD3

0.585

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPR173	WDR44	ENSP00000331600	ENSP00000254029	G protein-coupled receptor 173; Orphan receptor	WD repeat domain 44	0.633
GRB2	UBC	ENSP00000339007	ENSP00000344818	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	ubiquitin C	0.949
GRB2	WDR44	ENSP00000339007	ENSP00000254029	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	WD repeat domain 44	0.635
ILF2	UBC	ENSP00000355011	ENSP00000344818	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	ubiquitin C	0.992
ILF2	WDR44	ENSP00000355011	ENSP00000254029	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	WD repeat domain 44	0.644
LSM4	LSM7	ENSP00000469468	ENSP00000252622	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome	0.999
LSM4	UBC	ENSP00000469468	ENSP00000344818	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	ubiquitin C	0.721
LSM4	WDR44	ENSP00000469468	ENSP00000254029	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	WD repeat domain 44	0.906
LSM7	LSM4	ENSP00000252622	ENSP00000469468	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	0.999
LSM7	UBC	ENSP00000252622	ENSP00000344818	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome	ubiquitin C	0.807
LSM7	WDR44	ENSP00000252622	ENSP00000254029	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome	WD repeat domain 44	0.970
MPZL2	WDR44	ENSP00000278937	ENSP00000254029	myelin protein zero-like 2; Mediates homophilic cell-cell adhesion	WD repeat domain 44	0.622
RAB11A	UBC	ENSP00000261890	ENSP00000344818	RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...]	ubiquitin C	0.936
RAB11A	WDR44	ENSP00000261890	ENSP00000254029	RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...]	WD repeat domain 44	0.794
RWDD3	WDR44	ENSP00000359221	ENSP00000254029	RWD domain containing 3; Enhances the sumoylation of a number of proteins including HIF1A, PIAS and I-kappa-B, through direct interaction with UBC9. Has no effect on ubiquitination	WD repeat domain 44	0.585
SLC7A14	WDR44	ENSP00000231706	ENSP00000254029	solute carrier family 7 (orphan transporter), member 14	WD repeat domain 44	0.628
UBC	GRB2	ENSP00000344818	ENSP00000339007	ubiquitin C	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	0.949
UBC	ILF2	ENSP00000344818	ENSP00000355011	ubiquitin C	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	0.992
UBC	LSM4	ENSP00000344818	ENSP00000469468	ubiquitin C	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA	0.721
UBC	LSM7	ENSP00000344818	ENSP00000252622	ubiquitin C	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome	0.807

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