| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK1 | CKMT2 | ENSP00000362249 | ENSP00000254035 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.700 |
| AK1 | GOT1 | ENSP00000362249 | ENSP00000359539 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.525 |
| AK1 | GOT2 | ENSP00000362249 | ENSP00000245206 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.656 |
| AK1 | LDHA | ENSP00000362249 | ENSP00000445175 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | lactate dehydrogenase A | 0.623 |
| AK1 | LDHB | ENSP00000362249 | ENSP00000229319 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | lactate dehydrogenase B | 0.645 |
| AK1 | LDHC | ENSP00000362249 | ENSP00000280704 | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | lactate dehydrogenase C; Possible role in sperm motility | 0.629 |
| AK8 | CKMT2 | ENSP00000298545 | ENSP00000254035 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.756 |
| AK8 | GOT1 | ENSP00000298545 | ENSP00000359539 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.532 |
| AK8 | GOT2 | ENSP00000298545 | ENSP00000245206 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.527 |
| AK8 | LDHA | ENSP00000298545 | ENSP00000445175 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase A | 0.635 |
| AK8 | LDHB | ENSP00000298545 | ENSP00000229319 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase B | 0.652 |
| AK8 | LDHC | ENSP00000298545 | ENSP00000280704 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase C; Possible role in sperm motility | 0.684 |
| CKMT2 | AK1 | ENSP00000254035 | ENSP00000362249 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | adenylate kinase 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 0.700 |
| CKMT2 | AK8 | ENSP00000254035 | ENSP00000298545 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | 0.756 |
| CKMT2 | CLPB | ENSP00000254035 | ENSP00000294053 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.777 |
| CKMT2 | GAMT | ENSP00000254035 | ENSP00000403536 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | guanidinoacetate N-methyltransferase | 0.924 |
| CKMT2 | GOT1 | ENSP00000254035 | ENSP00000359539 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.757 |
| CKMT2 | GOT2 | ENSP00000254035 | ENSP00000245206 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.729 |
| CKMT2 | GPT2 | ENSP00000254035 | ENSP00000345282 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | glutamic pyruvate transaminase (alanine aminotransferase) 2; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate | 0.700 |
| CKMT2 | LDHA | ENSP00000254035 | ENSP00000445175 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | lactate dehydrogenase A | 0.810 |
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