| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FMO5 | GJA5 | ENSP00000254090 | ENSP00000271348 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | gap junction protein, alpha 5, 40kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | 0.454 |
| FMO5 | NPR1 | ENSP00000254090 | ENSP00000357669 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand | 0.653 |
| FMO5 | PGR | ENSP00000254090 | ENSP00000325120 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | 0.520 |
| FMO5 | PIAS1 | ENSP00000254090 | ENSP00000249636 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | protein inhibitor of activated STAT, 1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activ [...] | 0.410 |
| FMO5 | RB1 | ENSP00000254090 | ENSP00000267163 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.439 |
| FMO5 | WNT4 | ENSP00000254090 | ENSP00000290167 | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | wingless-type MMTV integration site family, member 4; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue | 0.439 |
| GJA5 | FMO5 | ENSP00000271348 | ENSP00000254090 | gap junction protein, alpha 5, 40kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.454 |
| NPR1 | FMO5 | ENSP00000357669 | ENSP00000254090 | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.653 |
| PGR | FMO5 | ENSP00000325120 | ENSP00000254090 | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.520 |
| PGR | RB1 | ENSP00000325120 | ENSP00000267163 | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.650 |
| PGR | WNT4 | ENSP00000325120 | ENSP00000290167 | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | wingless-type MMTV integration site family, member 4; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue | 0.502 |
| PIAS1 | FMO5 | ENSP00000249636 | ENSP00000254090 | protein inhibitor of activated STAT, 1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activ [...] | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.410 |
| RB1 | FMO5 | ENSP00000267163 | ENSP00000254090 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.439 |
| RB1 | PGR | ENSP00000267163 | ENSP00000325120 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | 0.650 |
| WNT4 | FMO5 | ENSP00000290167 | ENSP00000254090 | wingless-type MMTV integration site family, member 4; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue | flavin containing monooxygenase 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.439 |
| WNT4 | PGR | ENSP00000290167 | ENSP00000325120 | wingless-type MMTV integration site family, member 4; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | 0.502 |
Share
