node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPN1 | ZNF132 | ENSP00000406209 | ENSP00000254166 | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | zinc finger protein 132; May be involved in transcriptional regulation | 0.476 |
FBXL19 | ZNF132 | ENSP00000369666 | ENSP00000254166 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 132; May be involved in transcriptional regulation | 0.501 |
HTN3 | ZNF132 | ENSP00000432561 | ENSP00000254166 | histatin 3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | zinc finger protein 132; May be involved in transcriptional regulation | 0.607 |
KDM2A | ZNF132 | ENSP00000432786 | ENSP00000254166 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 132; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF132 | ENSP00000366271 | ENSP00000254166 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 132; May be involved in transcriptional regulation | 0.501 |
PTPN23 | ZNF132 | ENSP00000265562 | ENSP00000254166 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 132; May be involved in transcriptional regulation | 0.498 |
TAS2R50 | TMPRSS11B | ENSP00000424040 | ENSP00000330475 | taste receptor, type 2, member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) | transmembrane protease, serine 11B; Probable serine protease (By similarity) | 0.624 |
TAS2R50 | WDR31 | ENSP00000424040 | ENSP00000363308 | taste receptor, type 2, member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) | WD repeat domain 31 | 0.659 |
TAS2R50 | ZNF132 | ENSP00000424040 | ENSP00000254166 | taste receptor, type 2, member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) | zinc finger protein 132; May be involved in transcriptional regulation | 0.503 |
TMPRSS11B | TAS2R50 | ENSP00000330475 | ENSP00000424040 | transmembrane protease, serine 11B; Probable serine protease (By similarity) | taste receptor, type 2, member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) | 0.624 |
TMPRSS11B | WDR31 | ENSP00000330475 | ENSP00000363308 | transmembrane protease, serine 11B; Probable serine protease (By similarity) | WD repeat domain 31 | 0.700 |
TMPRSS11B | ZNF132 | ENSP00000330475 | ENSP00000254166 | transmembrane protease, serine 11B; Probable serine protease (By similarity) | zinc finger protein 132; May be involved in transcriptional regulation | 0.506 |
WDR31 | TAS2R50 | ENSP00000363308 | ENSP00000424040 | WD repeat domain 31 | taste receptor, type 2, member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) | 0.659 |
WDR31 | TMPRSS11B | ENSP00000363308 | ENSP00000330475 | WD repeat domain 31 | transmembrane protease, serine 11B; Probable serine protease (By similarity) | 0.700 |
WDR31 | ZNF132 | ENSP00000363308 | ENSP00000254166 | WD repeat domain 31 | zinc finger protein 132; May be involved in transcriptional regulation | 0.563 |
XRN1 | ZNF132 | ENSP00000264951 | ENSP00000254166 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 132; May be involved in transcriptional regulation | 0.543 |
ZNF132 | EPN1 | ENSP00000254166 | ENSP00000406209 | zinc finger protein 132; May be involved in transcriptional regulation | epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis | 0.476 |
ZNF132 | FBXL19 | ENSP00000254166 | ENSP00000369666 | zinc finger protein 132; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF132 | HTN3 | ENSP00000254166 | ENSP00000432561 | zinc finger protein 132; May be involved in transcriptional regulation | histatin 3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 | 0.607 |
ZNF132 | KDM2A | ENSP00000254166 | ENSP00000432786 | zinc finger protein 132; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |