node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR10 | ACTR1A | ENSP00000254286 | ENSP00000358921 | actin-related protein 10 homolog (S. cerevisiae) | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 0.911 |
ACTR10 | ACTR1B | ENSP00000254286 | ENSP00000289228 | actin-related protein 10 homolog (S. cerevisiae) | ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 0.800 |
ACTR10 | BMP7 | ENSP00000254286 | ENSP00000379204 | actin-related protein 10 homolog (S. cerevisiae) | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.855 |
ACTR10 | CFL1 | ENSP00000254286 | ENSP00000309629 | actin-related protein 10 homolog (S. cerevisiae) | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.798 |
ACTR10 | CFL2 | ENSP00000254286 | ENSP00000298159 | actin-related protein 10 homolog (S. cerevisiae) | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.798 |
ACTR10 | DCTN2 | ENSP00000254286 | ENSP00000408910 | actin-related protein 10 homolog (S. cerevisiae) | dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development | 0.911 |
ACTR10 | DCTN4 | ENSP00000254286 | ENSP00000414906 | actin-related protein 10 homolog (S. cerevisiae) | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.932 |
ACTR10 | DSTN | ENSP00000254286 | ENSP00000246069 | actin-related protein 10 homolog (S. cerevisiae) | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.809 |
ACTR10 | PLS1 | ENSP00000254286 | ENSP00000336831 | actin-related protein 10 homolog (S. cerevisiae) | plastin 1; Actin-bundling protein in the absence of calcium | 0.797 |
ACTR10 | UBC | ENSP00000254286 | ENSP00000344818 | actin-related protein 10 homolog (S. cerevisiae) | ubiquitin C | 0.819 |
ACTR1A | ACTR10 | ENSP00000358921 | ENSP00000254286 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | actin-related protein 10 homolog (S. cerevisiae) | 0.911 |
ACTR1A | ACTR1B | ENSP00000358921 | ENSP00000289228 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 0.999 |
ACTR1A | CFL1 | ENSP00000358921 | ENSP00000309629 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.801 |
ACTR1A | CFL2 | ENSP00000358921 | ENSP00000298159 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) | 0.798 |
ACTR1A | DCTN2 | ENSP00000358921 | ENSP00000408910 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development | 0.999 |
ACTR1A | DCTN4 | ENSP00000358921 | ENSP00000414906 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.994 |
ACTR1A | DSTN | ENSP00000358921 | ENSP00000246069 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.798 |
ACTR1A | PLS1 | ENSP00000358921 | ENSP00000336831 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | plastin 1; Actin-bundling protein in the absence of calcium | 0.775 |
ACTR1A | UBC | ENSP00000358921 | ENSP00000344818 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | ubiquitin C | 0.928 |
ACTR1B | ACTR10 | ENSP00000289228 | ENSP00000254286 | ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | actin-related protein 10 homolog (S. cerevisiae) | 0.800 |