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DCTN4 DCTN4 DCTN2 DCTN2 BMP7 BMP7 ACTR10 ACTR10 ACTR1B ACTR1B ACTR1A ACTR1A UBC UBC PLS1 PLS1 DSTN DSTN CFL2 CFL2 CFL1 CFL1
"ACTR10" - actin-related protein 10 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ACTR10actin-related protein 10 homolog (S. cerevisiae) (417 aa)    
Predicted Functional Partners:
DCTN4
dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (467 aa)
      score_image score_image score_image score_image   0.932
DCTN2
dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
      score_image score_image score_image score_image   0.911
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
        score_image score_image score_image score_image 0.911
BMP7
bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (431 aa)
            score_image   0.855
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.819
DSTN
destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner (165 aa)
      score_image score_image   score_image   0.809
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
        score_image score_image score_image score_image 0.800
CFL1
cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (166 aa)
      score_image score_image   score_image   0.798
CFL2
cofilin 2 (muscle); Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1-1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity) (166 aa)
      score_image score_image   score_image   0.798
PLS1
plastin 1; Actin-bundling protein in the absence of calcium (629 aa)
        score_image   score_image   0.797
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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