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STRINGSTRING
NTMT1 NTMT1 CUEDC1 CUEDC1 PHF7 PHF7 LUC7L2 LUC7L2 C19orf57 C19orf57 NECAB3 NECAB3 TSC22D3 TSC22D3 AIMP2 AIMP2 SCLT1 SCLT1 TMA16 TMA16 MZT2A MZT2A
"C19orf57" - chromosome 19 open reading frame 57 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
C19orf57chromosome 19 open reading frame 57 (637 aa)    
Predicted Functional Partners:
NECAB3
N-terminal EF-hand calcium binding protein 3 (396 aa)
            score_image   0.569
SCLT1
sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) (688 aa)
            score_image   0.539
TSC22D3
TSC22 domain family, member 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity) (200 aa)
        score_image       0.537
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor (320 aa)
        score_image       0.500
CUEDC1
CUE domain containing 1 (386 aa)
            score_image   0.472
TMA16
translation machinery associated 16 homolog (S. cerevisiae) (203 aa)
            score_image   0.422
NTMT1
N-terminal Xaa-Pro-Lys N-methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation vi [...] (223 aa)
            score_image   0.408
PHF7
PHD finger protein 7; May play a role in spermatogenesis (381 aa)
            score_image   0.408
MZT2A
mitotic spindle organizing protein 2A (158 aa)
            score_image   0.407
LUC7L2
LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain (392 aa)
            score_image   0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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