node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIMP2 | C19orf57 | ENSP00000223029 | ENSP00000254336 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | chromosome 19 open reading frame 57 | 0.500 |
C19orf57 | AIMP2 | ENSP00000254336 | ENSP00000223029 | chromosome 19 open reading frame 57 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | 0.500 |
C19orf57 | CUEDC1 | ENSP00000254336 | ENSP00000353373 | chromosome 19 open reading frame 57 | CUE domain containing 1 | 0.472 |
C19orf57 | LUC7L2 | ENSP00000254336 | ENSP00000347005 | chromosome 19 open reading frame 57 | LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | 0.404 |
C19orf57 | MZT2A | ENSP00000254336 | ENSP00000311500 | chromosome 19 open reading frame 57 | mitotic spindle organizing protein 2A | 0.407 |
C19orf57 | NECAB3 | ENSP00000254336 | ENSP00000246190 | chromosome 19 open reading frame 57 | N-terminal EF-hand calcium binding protein 3 | 0.569 |
C19orf57 | NTMT1 | ENSP00000254336 | ENSP00000361558 | chromosome 19 open reading frame 57 | N-terminal Xaa-Pro-Lys N-methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation vi [...] | 0.408 |
C19orf57 | PHF7 | ENSP00000254336 | ENSP00000333024 | chromosome 19 open reading frame 57 | PHD finger protein 7; May play a role in spermatogenesis | 0.408 |
C19orf57 | SCLT1 | ENSP00000254336 | ENSP00000281142 | chromosome 19 open reading frame 57 | sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | 0.539 |
C19orf57 | TMA16 | ENSP00000254336 | ENSP00000351380 | chromosome 19 open reading frame 57 | translation machinery associated 16 homolog (S. cerevisiae) | 0.422 |
C19orf57 | TSC22D3 | ENSP00000254336 | ENSP00000314655 | chromosome 19 open reading frame 57 | TSC22 domain family, member 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity) | 0.537 |
CUEDC1 | C19orf57 | ENSP00000353373 | ENSP00000254336 | CUE domain containing 1 | chromosome 19 open reading frame 57 | 0.472 |
LUC7L2 | C19orf57 | ENSP00000347005 | ENSP00000254336 | LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | chromosome 19 open reading frame 57 | 0.404 |
MZT2A | C19orf57 | ENSP00000311500 | ENSP00000254336 | mitotic spindle organizing protein 2A | chromosome 19 open reading frame 57 | 0.407 |
MZT2A | TMA16 | ENSP00000311500 | ENSP00000351380 | mitotic spindle organizing protein 2A | translation machinery associated 16 homolog (S. cerevisiae) | 0.407 |
NECAB3 | C19orf57 | ENSP00000246190 | ENSP00000254336 | N-terminal EF-hand calcium binding protein 3 | chromosome 19 open reading frame 57 | 0.569 |
NECAB3 | SCLT1 | ENSP00000246190 | ENSP00000281142 | N-terminal EF-hand calcium binding protein 3 | sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | 0.459 |
NTMT1 | C19orf57 | ENSP00000361558 | ENSP00000254336 | N-terminal Xaa-Pro-Lys N-methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation vi [...] | chromosome 19 open reading frame 57 | 0.408 |
PHF7 | C19orf57 | ENSP00000333024 | ENSP00000254336 | PHD finger protein 7; May play a role in spermatogenesis | chromosome 19 open reading frame 57 | 0.408 |
SCLT1 | C19orf57 | ENSP00000281142 | ENSP00000254336 | sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) | chromosome 19 open reading frame 57 | 0.539 |