| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAHD1 | RRP8 | ENSP00000396976 | ENSP00000254605 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | ribosomal RNA processing 8, methyltransferase, homolog (yeast); Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, [...] | 0.900 |
| BAHD1 | SIRT1 | ENSP00000396976 | ENSP00000212015 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...] | 0.900 |
| BAHD1 | SIRT2 | ENSP00000396976 | ENSP00000249396 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | sirtuin 2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates ’Lys-40’ of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates ’Lys-310’ of RELA | 0.900 |
| BAHD1 | SUV39H1 | ENSP00000396976 | ENSP00000365877 | bromo adjacent homology domain containing 1; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon- stimulated genes, including IFNL1, IFNL2 and IFNL3 | suppressor of variegation 3-9 homolog 1 (Drosophila); Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3 using monomethylated H3 ’Lys- 9’ as substrate. Also weakly methylates histone H1 (in vitro). H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 ’Lys-9’ trimethylation is [...] | 0.900 |
| MAK16 | NOP2 | ENSP00000353246 | ENSP00000382392 | MAK16 homolog (S. cerevisiae) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.836 |
| MAK16 | NSUN6 | ENSP00000353246 | ENSP00000366519 | MAK16 homolog (S. cerevisiae) | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.836 |
| MAK16 | RPF2 | ENSP00000353246 | ENSP00000402338 | MAK16 homolog (S. cerevisiae) | ribosome production factor 2 homolog (S. cerevisiae) | 0.923 |
| MAK16 | RRP1 | ENSP00000353246 | ENSP00000417464 | MAK16 homolog (S. cerevisiae) | ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA | 0.885 |
| MAK16 | RRP1B | ENSP00000353246 | ENSP00000339145 | MAK16 homolog (S. cerevisiae) | ribosomal RNA processing 1 homolog B (S. cerevisiae) | 0.885 |
| MAK16 | RRP8 | ENSP00000353246 | ENSP00000254605 | MAK16 homolog (S. cerevisiae) | ribosomal RNA processing 8, methyltransferase, homolog (yeast); Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, [...] | 0.894 |
| NOP2 | MAK16 | ENSP00000382392 | ENSP00000353246 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | MAK16 homolog (S. cerevisiae) | 0.836 |
| NOP2 | RPF2 | ENSP00000382392 | ENSP00000402338 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | ribosome production factor 2 homolog (S. cerevisiae) | 0.998 |
| NOP2 | RRP1 | ENSP00000382392 | ENSP00000417464 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA | 0.986 |
| NOP2 | RRP1B | ENSP00000382392 | ENSP00000339145 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | ribosomal RNA processing 1 homolog B (S. cerevisiae) | 0.985 |
| NOP2 | RRP8 | ENSP00000382392 | ENSP00000254605 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | ribosomal RNA processing 8, methyltransferase, homolog (yeast); Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, [...] | 0.860 |
| NSUN6 | MAK16 | ENSP00000366519 | ENSP00000353246 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | MAK16 homolog (S. cerevisiae) | 0.836 |
| NSUN6 | RPF2 | ENSP00000366519 | ENSP00000402338 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | ribosome production factor 2 homolog (S. cerevisiae) | 0.993 |
| NSUN6 | RRP1 | ENSP00000366519 | ENSP00000417464 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA | 0.923 |
| NSUN6 | RRP1B | ENSP00000366519 | ENSP00000339145 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | ribosomal RNA processing 1 homolog B (S. cerevisiae) | 0.923 |
| NSUN6 | RRP8 | ENSP00000366519 | ENSP00000254605 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | ribosomal RNA processing 8, methyltransferase, homolog (yeast); Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, [...] | 0.847 |
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