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STRINGSTRING
HHLA1 HHLA1 OTOG OTOG SLC26A4 SLC26A4 OC90 OC90 OTOP2 OTOP2 OTOL1 OTOL1 OTOP1 OTOP1 ATP2B2 ATP2B2 ATP2B4 ATP2B4 NOX3 NOX3 OTOP3 OTOP3
"OC90" - otoconin 90 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OC90otoconin 90; It is unlikely that this protein has phospholipase A2 activity (477 aa)    
Predicted Functional Partners:
HHLA1
HERV-H LTR-associating 1 (543 aa)
  score_image         score_image   0.868
OTOP1
otopetrin 1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) (612 aa)
            score_image   0.798
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (1243 aa)
            score_image   0.747
OTOL1
otolin 1 (477 aa)
            score_image   0.729
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (1205 aa)
            score_image   0.680
NOX3
NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (568 aa)
            score_image   0.644
SLC26A4
solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide (780 aa)
            score_image   0.600
OTOG
otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity) (2925 aa)
            score_image   0.569
OTOP2
otopetrin 2 (562 aa)
            score_image   0.561
OTOP3
otopetrin 3 (596 aa)
            score_image   0.561
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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