PER2 protein (Homo sapiens) - STRING network view

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PER2

period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation (By similarity) (1255 aa)

Predicted Functional Partners:

CRY1

0.999

CRY2

0.999

BTRC

0.999

CSNK1E

0.999

PER1

0.998

CSNK1D

0.997

ARNTL

0.997

BHLHE41

0.989

PER3

0.988

CLOCK

0.962

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	BHLHE41	ENSP00000374357	ENSP00000242728	aryl hydrocarbon receptor nuclear translocator-like	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	0.976
ARNTL	BTRC	ENSP00000374357	ENSP00000359206	aryl hydrocarbon receptor nuclear translocator-like	beta-transducin repeat containing E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of N [...]	0.943
ARNTL	CLOCK	ENSP00000374357	ENSP00000308741	aryl hydrocarbon receptor nuclear translocator-like	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	0.999
ARNTL	CRY1	ENSP00000374357	ENSP00000008527	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	CRY2	ENSP00000374357	ENSP00000406751	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	CSNK1D	ENSP00000374357	ENSP00000324464	aryl hydrocarbon receptor nuclear translocator-like	casein kinase 1, delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator [...]	0.985
ARNTL	CSNK1E	ENSP00000374357	ENSP00000352929	aryl hydrocarbon receptor nuclear translocator-like	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	0.999
ARNTL	PER1	ENSP00000374357	ENSP00000314420	aryl hydrocarbon receptor nuclear translocator-like	period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation. Can bind heme (By similarity)	0.997
ARNTL	PER2	ENSP00000374357	ENSP00000254657	aryl hydrocarbon receptor nuclear translocator-like	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.997
ARNTL	PER3	ENSP00000374357	ENSP00000355031	aryl hydrocarbon receptor nuclear translocator-like	period homolog 3 (Drosophila)	0.997
BHLHE41	ARNTL	ENSP00000242728	ENSP00000374357	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	aryl hydrocarbon receptor nuclear translocator-like	0.976
BHLHE41	BTRC	ENSP00000242728	ENSP00000359206	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	beta-transducin repeat containing E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of N [...]	0.960
BHLHE41	CLOCK	ENSP00000242728	ENSP00000308741	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	0.963
BHLHE41	CRY1	ENSP00000242728	ENSP00000008527	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.989
BHLHE41	CRY2	ENSP00000242728	ENSP00000406751	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.982
BHLHE41	CSNK1D	ENSP00000242728	ENSP00000324464	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	casein kinase 1, delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator [...]	0.756
BHLHE41	CSNK1E	ENSP00000242728	ENSP00000352929	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	0.973
BHLHE41	PER1	ENSP00000242728	ENSP00000314420	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation. Can bind heme (By similarity)	0.430
BHLHE41	PER2	ENSP00000242728	ENSP00000254657	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.989
BHLHE41	PER3	ENSP00000242728	ENSP00000355031	basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription	period homolog 3 (Drosophila)	0.798

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