EEFSEC protein (Homo sapiens) - STRING network view

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EEFSEC

eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (596 aa)

Predicted Functional Partners:

SECISBP2

0.994

TRNAU1AP

0.941

SEPHS1

0.935

PSTK

0.911

SEPHS2

0.868

VIMP

0.818

SEPSECS

0.807

SECISBP2L

0.797

RPL30

0.673

TRPT1

0.644

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEFSEC	PSTK	ENSP00000254730	ENSP00000357882	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	0.911
EEFSEC	RPL30	ENSP00000254730	ENSP00000287038	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	ribosomal protein L30	0.673
EEFSEC	SECISBP2	ENSP00000254730	ENSP00000364965	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB	0.994
EEFSEC	SECISBP2L	ENSP00000254730	ENSP00000453854	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	SECIS binding protein 2-like	0.797
EEFSEC	SEPHS1	ENSP00000254730	ENSP00000367893	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.935
EEFSEC	SEPHS2	ENSP00000254730	ENSP00000426234	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP	0.868
EEFSEC	SEPSECS	ENSP00000254730	ENSP00000371535	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	0.807
EEFSEC	TRNAU1AP	ENSP00000254730	ENSP00000362936	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	tRNA selenocysteine 1 associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity)	0.941
EEFSEC	TRPT1	ENSP00000254730	ENSP00000378050	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	tRNA phosphotransferase 1; Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2’-phosphate from ligated tRNA to NAD to produce ADP-ribose 1’’-2’’ cyclic phosphate (Probable)	0.644
EEFSEC	VIMP	ENSP00000254730	ENSP00000381282	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.818
PSTK	EEFSEC	ENSP00000357882	ENSP00000254730	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	0.911
PSTK	SECISBP2	ENSP00000357882	ENSP00000364965	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB	0.710
PSTK	SECISBP2L	ENSP00000357882	ENSP00000453854	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	SECIS binding protein 2-like	0.461
PSTK	SEPHS1	ENSP00000357882	ENSP00000367893	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.606
PSTK	SEPHS2	ENSP00000357882	ENSP00000426234	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP	0.681
PSTK	SEPSECS	ENSP00000357882	ENSP00000371535	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	Sep (O-phosphoserine) tRNA-Sec (selenocysteine) tRNA synthase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis	0.990
PSTK	TRNAU1AP	ENSP00000357882	ENSP00000362936	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	tRNA selenocysteine 1 associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity)	0.819
PSTK	VIMP	ENSP00000357882	ENSP00000381282	phosphoseryl-tRNA kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis (By similarity)	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.584
RPL30	EEFSEC	ENSP00000287038	ENSP00000254730	ribosomal protein L30	eukaryotic elongation factor, selenocysteine-tRNA-specific; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP	0.673
RPL30	SECISBP2	ENSP00000287038	ENSP00000364965	ribosomal protein L30	SECIS binding protein 2; Binds to the SECIS element in the 3’-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB	0.667

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