GRSF1 protein (Homo sapiens) - STRING network view

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GRSF1

G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element (480 aa)

Predicted Functional Partners:

GPX4

0.981

UBC

0.878

PTCD3

0.591

BDKRB2

0.569

PSMD10

0.569

MTPAP

0.546

C1QBP

0.515

MRPS15

0.509

TFAM

0.508

TRMT10C

0.507

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDKRB2	GRSF1	ENSP00000307713	ENSP00000254799	bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	0.569
C1QBP	GRSF1	ENSP00000225698	ENSP00000254799	complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...]	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	0.515
C1QBP	PTCD3	ENSP00000225698	ENSP00000254630	complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...]	pentatricopeptide repeat domain 3; Mitochondrial RNA-binding protein that has a role in mitochondrial translation	0.480
C1QBP	TFAM	ENSP00000225698	ENSP00000420588	complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...]	transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and c [...]	0.434
C1QBP	UBC	ENSP00000225698	ENSP00000344818	complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...]	ubiquitin C	0.904
GPX4	GRSF1	ENSP00000346103	ENSP00000254799	glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	0.981
GPX4	UBC	ENSP00000346103	ENSP00000344818	glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)	ubiquitin C	0.679
GRSF1	BDKRB2	ENSP00000254799	ENSP00000307713	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system	0.569
GRSF1	C1QBP	ENSP00000254799	ENSP00000225698	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...]	0.515
GRSF1	GPX4	ENSP00000254799	ENSP00000346103	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)	0.981
GRSF1	MRPS15	ENSP00000254799	ENSP00000362208	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	mitochondrial ribosomal protein S15	0.509
GRSF1	MTPAP	ENSP00000254799	ENSP00000263063	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	mitochondrial poly(A) polymerase; Polymerase that creates the 3’ poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA	0.546
GRSF1	PSMD10	ENSP00000254799	ENSP00000217958	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10-PSMC4-PSMC5-PAAF1 module which probably assembles with a PSMD5-PSMC2-PSMC1-PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis	0.569
GRSF1	PTCD3	ENSP00000254799	ENSP00000254630	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	pentatricopeptide repeat domain 3; Mitochondrial RNA-binding protein that has a role in mitochondrial translation	0.591
GRSF1	TFAM	ENSP00000254799	ENSP00000420588	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and c [...]	0.508
GRSF1	TRMT10C	ENSP00000254799	ENSP00000312356	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends	0.507
GRSF1	UBC	ENSP00000254799	ENSP00000344818	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	ubiquitin C	0.878
MRPS15	GRSF1	ENSP00000362208	ENSP00000254799	mitochondrial ribosomal protein S15	G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element	0.509
MRPS15	PTCD3	ENSP00000362208	ENSP00000254630	mitochondrial ribosomal protein S15	pentatricopeptide repeat domain 3; Mitochondrial RNA-binding protein that has a role in mitochondrial translation	0.595
MRPS15	TRMT10C	ENSP00000362208	ENSP00000312356	mitochondrial ribosomal protein S15	tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends	0.630

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