node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NEDD4 | SRC | ENSP00000345530 | ENSP00000350941 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.785 |
NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
NEDD4 | WBP1 | ENSP00000345530 | ENSP00000233615 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | WW domain binding protein 1 | 0.595 |
NEDD4 | WBP2 | ENSP00000345530 | ENSP00000254806 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | WW domain binding protein 2 | 0.865 |
NEDD4L | UBC | ENSP00000383199 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
NEDD4L | WBP2 | ENSP00000383199 | ENSP00000254806 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WW domain binding protein 2 | 0.875 |
NEDD4L | WWP1 | ENSP00000383199 | ENSP00000265428 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.929 |
SRC | NEDD4 | ENSP00000350941 | ENSP00000345530 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.785 |
SRC | UBC | ENSP00000350941 | ENSP00000344818 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | ubiquitin C | 0.995 |
SRC | WBP2 | ENSP00000350941 | ENSP00000254806 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | WW domain binding protein 2 | 0.853 |
SRC | YAP1 | ENSP00000350941 | ENSP00000282441 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...] | 0.673 |
SRC | YES1 | ENSP00000350941 | ENSP00000324740 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific j [...] | 0.901 |
UBC | NEDD4 | ENSP00000344818 | ENSP00000345530 | ubiquitin C | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.999 |
UBC | NEDD4L | ENSP00000344818 | ENSP00000383199 | ubiquitin C | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.999 |
UBC | SRC | ENSP00000344818 | ENSP00000350941 | ubiquitin C | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.995 |
UBC | WBP2 | ENSP00000344818 | ENSP00000254806 | ubiquitin C | WW domain binding protein 2 | 0.946 |
UBC | WWP1 | ENSP00000344818 | ENSP00000265428 | ubiquitin C | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.999 |
UBC | WWP2 | ENSP00000344818 | ENSP00000348283 | ubiquitin C | WW domain containing E3 ubiquitin protein ligase 2 | 0.998 |
UBC | YAP1 | ENSP00000344818 | ENSP00000282441 | ubiquitin C | Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...] | 0.988 |
UBC | YES1 | ENSP00000344818 | ENSP00000324740 | ubiquitin C | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific j [...] | 0.857 |