node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPA1 | HAPLN2 | ENSP00000011292 | ENSP00000255039 | carboxypeptidase A1 (pancreatic) | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.485 |
CPA2 | HAO2 | ENSP00000222481 | ENSP00000316339 | carboxypeptidase A2 (pancreatic) | hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids | 0.407 |
CPA2 | HAPLN2 | ENSP00000222481 | ENSP00000255039 | carboxypeptidase A2 (pancreatic) | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.515 |
CPA4 | HAPLN2 | ENSP00000222482 | ENSP00000255039 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.485 |
CPA5 | HAPLN2 | ENSP00000347549 | ENSP00000255039 | carboxypeptidase A5 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.485 |
ECHDC2 | HAPLN2 | ENSP00000360577 | ENSP00000255039 | enoyl CoA hydratase domain containing 2 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.481 |
ECHDC2 | LRRC8A | ENSP00000360577 | ENSP00000259324 | enoyl CoA hydratase domain containing 2 | leucine rich repeat containing 8 family, member A; Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity) | 0.462 |
GLRB | HAPLN2 | ENSP00000264428 | ENSP00000255039 | glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.484 |
HAO1 | HAPLN2 | ENSP00000368066 | ENSP00000255039 | hydroxyacid oxidase (glycolate oxidase) 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.483 |
HAO2 | CPA2 | ENSP00000316339 | ENSP00000222481 | hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids | carboxypeptidase A2 (pancreatic) | 0.407 |
HAO2 | HAPLN2 | ENSP00000316339 | ENSP00000255039 | hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.607 |
HAPLN2 | CPA1 | ENSP00000255039 | ENSP00000011292 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | carboxypeptidase A1 (pancreatic) | 0.485 |
HAPLN2 | CPA2 | ENSP00000255039 | ENSP00000222481 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | carboxypeptidase A2 (pancreatic) | 0.515 |
HAPLN2 | CPA4 | ENSP00000255039 | ENSP00000222482 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.485 |
HAPLN2 | CPA5 | ENSP00000255039 | ENSP00000347549 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | carboxypeptidase A5 | 0.485 |
HAPLN2 | ECHDC2 | ENSP00000255039 | ENSP00000360577 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | enoyl CoA hydratase domain containing 2 | 0.481 |
HAPLN2 | GLRB | ENSP00000255039 | ENSP00000264428 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | 0.484 |
HAPLN2 | HAO1 | ENSP00000255039 | ENSP00000368066 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | hydroxyacid oxidase (glycolate oxidase) 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate | 0.483 |
HAPLN2 | HAO2 | ENSP00000255039 | ENSP00000316339 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids | 0.607 |
HAPLN2 | JOSD2 | ENSP00000255039 | ENSP00000375691 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | Josephin domain containing 2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme | 0.513 |