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STRINGSTRING
HAO1 HAO1 CPA2 CPA2 JOSD2 JOSD2 CPA5 CPA5 HAO2 HAO2 HAPLN2 HAPLN2 GLRB GLRB CPA1 CPA1 CPA4 CPA4 LRRC8A LRRC8A ECHDC2 ECHDC2
"HAPLN2" - hyaluronan and proteoglycan link protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
HAPLN2hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) (340 aa)    
Predicted Functional Partners:
HAO2
hydroxyacid oxidase 2 (long chain); Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids (351 aa)
            score_image   0.607
CPA2
carboxypeptidase A2 (pancreatic) (419 aa)
            score_image   0.515
JOSD2
Josephin domain containing 2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (188 aa)
            score_image   0.513
CPA5
carboxypeptidase A5 (436 aa)
            score_image   0.485
CPA4
carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway (421 aa)
            score_image   0.485
CPA1
carboxypeptidase A1 (pancreatic) (419 aa)
            score_image   0.485
GLRB
glycine receptor, beta; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (497 aa)
            score_image   0.484
HAO1
hydroxyacid oxidase (glycolate oxidase) 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate (370 aa)
            score_image   0.483
ECHDC2
enoyl CoA hydratase domain containing 2 (292 aa)
            score_image   0.481
LRRC8A
leucine rich repeat containing 8 family, member A; Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity) (810 aa)
        score_image   score_image   0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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