Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
TTR TTR SAA1 SAA1 PRL PRL FGA FGA SNCA SNCA GSN GSN LTF LTF APOA1 APOA1 APP APP APCS APCS FCGR2A FCGR2A
"APCS" - amyloid P component, serum in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APCSamyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin (223 aa)    
Predicted Functional Partners:
SAA1
serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) (122 aa)
          score_image score_image   0.927
TTR
transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (147 aa)
      score_image   score_image score_image   0.925
FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens (317 aa)
        score_image   score_image   0.923
GSN
gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (782 aa)
          score_image score_image   0.915
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation (140 aa)
          score_image score_image   0.912
FGA
fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (866 aa)
      score_image   score_image score_image   0.912
APOA1
apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (267 aa)
      score_image   score_image score_image   0.911
PRL
prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
          score_image score_image   0.909
LTF
lactotransferrin (710 aa)
          score_image score_image   0.908
APP
amyloid beta (A4) precursor protein (770 aa)
          score_image score_image   0.906
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (25%)