node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APCS | APOA1 | ENSP00000255040 | ENSP00000236850 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.911 |
APCS | APP | ENSP00000255040 | ENSP00000284981 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | amyloid beta (A4) precursor protein | 0.906 |
APCS | FCGR2A | ENSP00000255040 | ENSP00000271450 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | Fc fragment of IgG, low affinity IIa, receptor (CD32); Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens | 0.923 |
APCS | FGA | ENSP00000255040 | ENSP00000306361 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.912 |
APCS | GSN | ENSP00000255040 | ENSP00000362924 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.915 |
APCS | LTF | ENSP00000255040 | ENSP00000231751 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | lactotransferrin | 0.908 |
APCS | PRL | ENSP00000255040 | ENSP00000302150 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | 0.909 |
APCS | SAA1 | ENSP00000255040 | ENSP00000348918 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.927 |
APCS | SNCA | ENSP00000255040 | ENSP00000338345 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.912 |
APCS | TTR | ENSP00000255040 | ENSP00000237014 | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.925 |
APOA1 | APCS | ENSP00000236850 | ENSP00000255040 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | 0.911 |
APOA1 | APP | ENSP00000236850 | ENSP00000284981 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | amyloid beta (A4) precursor protein | 0.964 |
APOA1 | FGA | ENSP00000236850 | ENSP00000306361 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.983 |
APOA1 | GSN | ENSP00000236850 | ENSP00000362924 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis | 0.943 |
APOA1 | LTF | ENSP00000236850 | ENSP00000231751 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | lactotransferrin | 0.915 |
APOA1 | PRL | ENSP00000236850 | ENSP00000302150 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | 0.902 |
APOA1 | SAA1 | ENSP00000236850 | ENSP00000348918 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.948 |
APOA1 | SNCA | ENSP00000236850 | ENSP00000338345 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.913 |
APOA1 | TTR | ENSP00000236850 | ENSP00000237014 | apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain | 0.986 |
APP | APCS | ENSP00000284981 | ENSP00000255040 | amyloid beta (A4) precursor protein | amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin | 0.906 |