SERINC3 protein (Homo sapiens) - STRING network view

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SERINC3

serine incorporator 3; May be involved in cellular transformation (473 aa)

Predicted Functional Partners:

GRXCR1

0.910

CLGN

0.757

PARL

0.723

UBXN11

0.700

ENG

0.700

SH3GL1

0.681

COL14A1

0.658

MSRB1

0.648

LIAS

0.631

PHB2

0.609

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLGN	SERINC3	ENSP00000326699	ENSP00000255175	calmegin; Probably plays an important role in spermatogenesis. Binds calcium ions	serine incorporator 3; May be involved in cellular transformation	0.757
COL14A1	ENG	ENSP00000297848	ENSP00000362299	collagen, type XIV, alpha 1	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	0.757
COL14A1	LIAS	ENSP00000297848	ENSP00000261434	collagen, type XIV, alpha 1	lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)	0.754
COL14A1	MSRB1	ENSP00000297848	ENSP00000355084	collagen, type XIV, alpha 1	methionine sulfoxide reductase B1	0.729
COL14A1	PARL	ENSP00000297848	ENSP00000325421	collagen, type XIV, alpha 1	presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain	0.824
COL14A1	PHB2	ENSP00000297848	ENSP00000441875	collagen, type XIV, alpha 1	prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging	0.567
COL14A1	SERINC3	ENSP00000297848	ENSP00000255175	collagen, type XIV, alpha 1	serine incorporator 3; May be involved in cellular transformation	0.658
COL14A1	SH3GL1	ENSP00000297848	ENSP00000269886	collagen, type XIV, alpha 1	SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)	0.725
COL14A1	UBXN11	ENSP00000297848	ENSP00000363338	collagen, type XIV, alpha 1	UBX domain protein 11	0.772
ENG	COL14A1	ENSP00000362299	ENSP00000297848	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	collagen, type XIV, alpha 1	0.757
ENG	LIAS	ENSP00000362299	ENSP00000261434	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)	0.725
ENG	MSRB1	ENSP00000362299	ENSP00000355084	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	methionine sulfoxide reductase B1	0.725
ENG	PARL	ENSP00000362299	ENSP00000325421	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain	0.822
ENG	PHB2	ENSP00000362299	ENSP00000441875	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging	0.513
ENG	SERINC3	ENSP00000362299	ENSP00000255175	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	serine incorporator 3; May be involved in cellular transformation	0.700
ENG	SH3GL1	ENSP00000362299	ENSP00000269886	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)	0.757
ENG	UBXN11	ENSP00000362299	ENSP00000363338	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	UBX domain protein 11	0.810
GRXCR1	SERINC3	ENSP00000382670	ENSP00000255175	glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity)	serine incorporator 3; May be involved in cellular transformation	0.910
LIAS	COL14A1	ENSP00000261434	ENSP00000297848	lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)	collagen, type XIV, alpha 1	0.754
LIAS	ENG	ENSP00000261434	ENSP00000362299	lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)	endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors	0.725

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