DMGDH protein (Homo sapiens) - STRING network view

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Score

DMGDH

dimethylglycine dehydrogenase (866 aa)

Predicted Functional Partners:

GLDC

0.997

GCSH

0.995

BHMT

0.976

GNMT

0.959

SARDH

0.924

MTHFD1L

0.915

PIPOX

0.915

MTHFD1

0.891

SHMT1

0.864

SHMT2

0.862

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BHMT	DMGDH	ENSP00000274353	ENSP00000255189	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	dimethylglycine dehydrogenase	0.976
BHMT	GNMT	ENSP00000274353	ENSP00000361894	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine	0.767
BHMT	MTHFD1	ENSP00000274353	ENSP00000450560	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.763
BHMT	MTHFD1L	ENSP00000274353	ENSP00000356290	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.556
BHMT	SARDH	ENSP00000274353	ENSP00000360938	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	sarcosine dehydrogenase	0.611
BHMT	SHMT1	ENSP00000274353	ENSP00000318868	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.690
BHMT	SHMT2	ENSP00000274353	ENSP00000333667	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.602
DMGDH	BHMT	ENSP00000255189	ENSP00000274353	dimethylglycine dehydrogenase	betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline	0.976
DMGDH	GCSH	ENSP00000255189	ENSP00000319531	dimethylglycine dehydrogenase	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.995
DMGDH	GLDC	ENSP00000255189	ENSP00000370737	dimethylglycine dehydrogenase	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.997
DMGDH	GNMT	ENSP00000255189	ENSP00000361894	dimethylglycine dehydrogenase	glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine	0.959
DMGDH	MTHFD1	ENSP00000255189	ENSP00000450560	dimethylglycine dehydrogenase	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.891
DMGDH	MTHFD1L	ENSP00000255189	ENSP00000356290	dimethylglycine dehydrogenase	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.915
DMGDH	PIPOX	ENSP00000255189	ENSP00000317721	dimethylglycine dehydrogenase	pipecolic acid oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline	0.915
DMGDH	SARDH	ENSP00000255189	ENSP00000360938	dimethylglycine dehydrogenase	sarcosine dehydrogenase	0.924
DMGDH	SHMT1	ENSP00000255189	ENSP00000318868	dimethylglycine dehydrogenase	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.864
DMGDH	SHMT2	ENSP00000255189	ENSP00000333667	dimethylglycine dehydrogenase	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.862
GCSH	DMGDH	ENSP00000319531	ENSP00000255189	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	dimethylglycine dehydrogenase	0.995
GCSH	GLDC	ENSP00000319531	ENSP00000370737	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.999
GCSH	MTHFD1	ENSP00000319531	ENSP00000450560	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.740

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