| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARAP1 | C2CD4B | ENSP00000377233 | ENSP00000369755 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | 0.472 |
| ARAP1 | KLF14 | ENSP00000377233 | ENSP00000310878 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | Kruppel-like factor 14 | 0.582 |
| ARAP1 | ZBED3 | ENSP00000377233 | ENSP00000255198 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | 0.405 |
| ARAP1 | ZFAND6 | ENSP00000377233 | ENSP00000261749 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | zinc finger, AN1-type domain 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of ’Lys-48’- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity) | 0.505 |
| AXIN1 | AXIN2 | ENSP00000262320 | ENSP00000302625 | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) | 0.980 |
| AXIN1 | ZBED3 | ENSP00000262320 | ENSP00000255198 | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | 0.785 |
| AXIN2 | AXIN1 | ENSP00000302625 | ENSP00000262320 | axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | 0.980 |
| AXIN2 | ZBED3 | ENSP00000302625 | ENSP00000255198 | axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | 0.623 |
| C2CD4B | ARAP1 | ENSP00000369755 | ENSP00000377233 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.472 |
| C2CD4B | KLF14 | ENSP00000369755 | ENSP00000310878 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | Kruppel-like factor 14 | 0.457 |
| C2CD4B | ZBED3 | ENSP00000369755 | ENSP00000255198 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | 0.407 |
| C2CD4B | ZFAND6 | ENSP00000369755 | ENSP00000261749 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | zinc finger, AN1-type domain 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of ’Lys-48’- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity) | 0.418 |
| KLF14 | ARAP1 | ENSP00000310878 | ENSP00000377233 | Kruppel-like factor 14 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.582 |
| KLF14 | C2CD4B | ENSP00000310878 | ENSP00000369755 | Kruppel-like factor 14 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | 0.457 |
| KLF14 | ZBED3 | ENSP00000310878 | ENSP00000255198 | Kruppel-like factor 14 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | 0.510 |
| KLF14 | ZFAND6 | ENSP00000310878 | ENSP00000261749 | Kruppel-like factor 14 | zinc finger, AN1-type domain 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of ’Lys-48’- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity) | 0.586 |
| ZBED3 | ARAP1 | ENSP00000255198 | ENSP00000377233 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 0.405 |
| ZBED3 | AXIN1 | ENSP00000255198 | ENSP00000262320 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | 0.785 |
| ZBED3 | AXIN2 | ENSP00000255198 | ENSP00000302625 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) | 0.623 |
| ZBED3 | C2CD4B | ENSP00000255198 | ENSP00000369755 | zinc finger, BED-type containing 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity) | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | 0.407 |
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