| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX25 | NXF3 | ENSP00000263576 | ENSP00000378504 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | 0.630 |
| DDX25 | PIWIL1 | ENSP00000263576 | ENSP00000245255 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.585 |
| DDX25 | PIWIL2 | ENSP00000263576 | ENSP00000349208 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | piwi-like 2 (Drosophila) | 0.511 |
| DDX25 | PIWIL4 | ENSP00000263576 | ENSP00000299001 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.512 |
| DDX25 | RNF17 | ENSP00000263576 | ENSP00000255324 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.589 |
| DDX25 | TEX11 | ENSP00000263576 | ENSP00000340995 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) | 0.477 |
| MEIG1 | NXF3 | ENSP00000367486 | ENSP00000378504 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | 0.665 |
| MEIG1 | RNF17 | ENSP00000367486 | ENSP00000255324 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.579 |
| MEIG1 | SYCP2 | ENSP00000367486 | ENSP00000350162 | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) | 0.541 |
| NXF3 | DDX25 | ENSP00000378504 | ENSP00000263576 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.630 |
| NXF3 | MEIG1 | ENSP00000378504 | ENSP00000367486 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | meiosis expressed gene 1 homolog (mouse); Essential for spermiogenesis (By similarity) | 0.665 |
| NXF3 | RNF17 | ENSP00000378504 | ENSP00000255324 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.572 |
| NXF3 | SYCP2 | ENSP00000378504 | ENSP00000350162 | nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor | synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity) | 0.512 |
| PIWIL1 | DDX25 | ENSP00000245255 | ENSP00000263576 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.585 |
| PIWIL1 | RNF17 | ENSP00000245255 | ENSP00000255324 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.596 |
| PIWIL1 | STK31 | ENSP00000245255 | ENSP00000348132 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | serine/threonine kinase 31 | 0.472 |
| PIWIL1 | TDRD9 | ENSP00000245255 | ENSP00000387303 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | tudor domain containing 9; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity) | 0.837 |
| PIWIL2 | DDX25 | ENSP00000349208 | ENSP00000263576 | piwi-like 2 (Drosophila) | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.511 |
| PIWIL2 | PIWIL4 | ENSP00000349208 | ENSP00000299001 | piwi-like 2 (Drosophila) | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.411 |
| PIWIL2 | RNF17 | ENSP00000349208 | ENSP00000255324 | piwi-like 2 (Drosophila) | ring finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity) | 0.683 |
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