MYBPH protein (Homo sapiens) - STRING network view

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MYBPH

myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band (477 aa)

Predicted Functional Partners:

MYH14

0.945

MYBPC2

0.799

MYH3

0.746

MYH8

0.715

MYH6

0.707

MYH7

0.686

PROC

0.658

MYH4

0.642

MYH1

0.635

ROCK1

0.628

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MYBPC2	MYBPH	ENSP00000350332	ENSP00000255416	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	0.799
MYBPC2	MYH1	ENSP00000350332	ENSP00000226207	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction	0.733
MYBPC2	MYH14	ENSP00000350332	ENSP00000262269	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 14, non-muscle	0.943
MYBPC2	MYH3	ENSP00000350332	ENSP00000226209	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	0.928
MYBPC2	MYH4	ENSP00000350332	ENSP00000255381	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 4, skeletal muscle; Muscle contraction	0.623
MYBPC2	MYH6	ENSP00000350332	ENSP00000348634	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction	0.927
MYBPC2	MYH7	ENSP00000350332	ENSP00000347507	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 7, cardiac muscle, beta	0.665
MYBPC2	MYH8	ENSP00000350332	ENSP00000384330	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	0.921
MYBPC2	PROC	ENSP00000350332	ENSP00000234071	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	protein C (inactivator of coagulation factors Va and VIIIa); Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids	0.608
MYBPH	MYBPC2	ENSP00000255416	ENSP00000350332	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	0.799
MYBPH	MYH1	ENSP00000255416	ENSP00000226207	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction	0.635
MYBPH	MYH14	ENSP00000255416	ENSP00000262269	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 14, non-muscle	0.945
MYBPH	MYH3	ENSP00000255416	ENSP00000226209	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction	0.746
MYBPH	MYH4	ENSP00000255416	ENSP00000255381	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 4, skeletal muscle; Muscle contraction	0.642
MYBPH	MYH6	ENSP00000255416	ENSP00000348634	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction	0.707
MYBPH	MYH7	ENSP00000255416	ENSP00000347507	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 7, cardiac muscle, beta	0.686
MYBPH	MYH8	ENSP00000255416	ENSP00000384330	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction	0.715
MYBPH	PROC	ENSP00000255416	ENSP00000234071	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	protein C (inactivator of coagulation factors Va and VIIIa); Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids	0.658
MYBPH	ROCK1	ENSP00000255416	ENSP00000382697	myosin binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band	Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...]	0.628
MYH1	MYBPC2	ENSP00000226207	ENSP00000350332	myosin, heavy chain 1, skeletal muscle, adult; Muscle contraction	myosin binding protein C, fast type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role	0.733

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