node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF7IP | BTG1 | ENSP00000261168 | ENSP00000256015 | activating transcription factor 7 interacting protein; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 ’Lys-9’ (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcr [...] | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | 0.820 |
BTG1 | ATF7IP | ENSP00000256015 | ENSP00000261168 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | activating transcription factor 7 interacting protein; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 ’Lys-9’ (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcr [...] | 0.820 |
BTG1 | CCNA2 | ENSP00000256015 | ENSP00000274026 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.576 |
BTG1 | CHAF1A | ENSP00000256015 | ENSP00000301280 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | 0.982 |
BTG1 | CHAF1B | ENSP00000256015 | ENSP00000315700 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | chromatin assembly factor 1, subunit B (p60); Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer | 0.919 |
BTG1 | CNOT7 | ENSP00000256015 | ENSP00000355279 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.939 |
BTG1 | CNOT8 | ENSP00000256015 | ENSP00000285896 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.971 |
BTG1 | HOXB9 | ENSP00000256015 | ENSP00000309439 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | homeobox B9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | 0.599 |
BTG1 | PRMT1 | ENSP00000256015 | ENSP00000406162 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | protein arginine methyltransferase 1 | 0.998 |
BTG1 | RARA | ENSP00000256015 | ENSP00000254066 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | retinoic acid receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcrip [...] | 0.590 |
BTG1 | THRB | ENSP00000256015 | ENSP00000348827 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.576 |
CCNA2 | BTG1 | ENSP00000274026 | ENSP00000256015 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | 0.576 |
CCNA2 | CHAF1A | ENSP00000274026 | ENSP00000301280 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | 0.699 |
CHAF1A | BTG1 | ENSP00000301280 | ENSP00000256015 | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | 0.982 |
CHAF1A | CCNA2 | ENSP00000301280 | ENSP00000274026 | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.699 |
CHAF1A | CHAF1B | ENSP00000301280 | ENSP00000315700 | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | chromatin assembly factor 1, subunit B (p60); Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer | 0.999 |
CHAF1A | CNOT7 | ENSP00000301280 | ENSP00000355279 | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.496 |
CHAF1A | CNOT8 | ENSP00000301280 | ENSP00000285896 | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.499 |
CHAF1B | BTG1 | ENSP00000315700 | ENSP00000256015 | chromatin assembly factor 1, subunit B (p60); Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | 0.919 |
CHAF1B | CHAF1A | ENSP00000315700 | ENSP00000301280 | chromatin assembly factor 1, subunit B (p60); Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer | chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] | 0.999 |