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STRINGSTRING
PEX19 PEX19 HNF4G HNF4G HNF4A HNF4A DSTN DSTN PMP22 PMP22 PMP2 PMP2 FABP6 FABP6 EGR2 EGR2 GDAP1 GDAP1 MAP9 MAP9 FGD4 FGD4
"PMP2" - peripheral myelin protein 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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Score
PMP2peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol (132 aa)    
Predicted Functional Partners:
GDAP1
ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission (358 aa)
            score_image   0.860
EGR2
early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 (476 aa)
            score_image   0.844
DSTN
destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner (165 aa)
            score_image   0.749
MAP9
microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (647 aa)
            score_image   0.748
HNF4G
hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha (445 aa)
            score_image   0.699
HNF4A
hepatocyte nuclear factor 4, alpha (474 aa)
            score_image   0.699
FABP6
fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis (177 aa)
            score_image   0.659
PEX19
peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa)
            score_image   0.606
PMP22
peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system (160 aa)
            score_image   0.516
FGD4
FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) (766 aa)
            score_image   0.487
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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