node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DSTN | EGR2 | ENSP00000246069 | ENSP00000242480 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.623 |
DSTN | GDAP1 | ENSP00000246069 | ENSP00000220822 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | 0.561 |
DSTN | PEX19 | ENSP00000246069 | ENSP00000357051 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.644 |
DSTN | PMP2 | ENSP00000246069 | ENSP00000256103 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol | 0.749 |
DSTN | PMP22 | ENSP00000246069 | ENSP00000308937 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | 0.440 |
EGR2 | DSTN | ENSP00000242480 | ENSP00000246069 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.623 |
EGR2 | GDAP1 | ENSP00000242480 | ENSP00000220822 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | 0.566 |
EGR2 | PMP2 | ENSP00000242480 | ENSP00000256103 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol | 0.844 |
EGR2 | PMP22 | ENSP00000242480 | ENSP00000308937 | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | 0.912 |
FABP6 | HNF4A | ENSP00000377549 | ENSP00000312987 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | hepatocyte nuclear factor 4, alpha | 0.798 |
FABP6 | HNF4G | ENSP00000377549 | ENSP00000379701 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.699 |
FABP6 | PMP2 | ENSP00000377549 | ENSP00000256103 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol | 0.659 |
FGD4 | GDAP1 | ENSP00000394487 | ENSP00000220822 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | 0.750 |
FGD4 | PMP2 | ENSP00000394487 | ENSP00000256103 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol | 0.487 |
GDAP1 | DSTN | ENSP00000220822 | ENSP00000246069 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.561 |
GDAP1 | EGR2 | ENSP00000220822 | ENSP00000242480 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 | 0.566 |
GDAP1 | FGD4 | ENSP00000220822 | ENSP00000394487 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | 0.750 |
GDAP1 | MAP9 | ENSP00000220822 | ENSP00000310593 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules | 0.563 |
GDAP1 | PMP2 | ENSP00000220822 | ENSP00000256103 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol | 0.860 |
GDAP1 | PMP22 | ENSP00000220822 | ENSP00000308937 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | 0.749 |