node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGMO | C14orf1 | ENSP00000341662 | ENSP00000256319 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | chromosome 14 open reading frame 1 | 0.889 |
AGMO | C5orf4 | ENSP00000341662 | ENSP00000320604 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | chromosome 5 open reading frame 4 | 0.912 |
AGMO | CH25H | ENSP00000341662 | ENSP00000360918 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.899 |
AGMO | FDFT1 | ENSP00000341662 | ENSP00000220584 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | farnesyl-diphosphate farnesyltransferase 1 | 0.922 |
AGMO | HSD17B7 | ENSP00000341662 | ENSP00000254521 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols | 0.844 |
AGMO | LSS | ENSP00000341662 | ENSP00000348762 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.851 |
AGMO | MSMO1 | ENSP00000341662 | ENSP00000261507 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | methylsterol monooxygenase 1 | 0.898 |
AGMO | NSDHL | ENSP00000341662 | ENSP00000359297 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | NAD(P) dependent steroid dehydrogenase-like | 0.717 |
AGMO | SIGMAR1 | ENSP00000341662 | ENSP00000277010 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | sigma non-opioid intracellular receptor 1 | 0.745 |
C14orf1 | AGMO | ENSP00000256319 | ENSP00000341662 | chromosome 14 open reading frame 1 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.889 |
C14orf1 | C5orf4 | ENSP00000256319 | ENSP00000320604 | chromosome 14 open reading frame 1 | chromosome 5 open reading frame 4 | 0.859 |
C14orf1 | CH25H | ENSP00000256319 | ENSP00000360918 | chromosome 14 open reading frame 1 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.858 |
C14orf1 | FDFT1 | ENSP00000256319 | ENSP00000220584 | chromosome 14 open reading frame 1 | farnesyl-diphosphate farnesyltransferase 1 | 0.956 |
C14orf1 | HSD17B7 | ENSP00000256319 | ENSP00000254521 | chromosome 14 open reading frame 1 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols | 0.957 |
C14orf1 | LSS | ENSP00000256319 | ENSP00000348762 | chromosome 14 open reading frame 1 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.956 |
C14orf1 | MSMO1 | ENSP00000256319 | ENSP00000261507 | chromosome 14 open reading frame 1 | methylsterol monooxygenase 1 | 0.916 |
C14orf1 | NSDHL | ENSP00000256319 | ENSP00000359297 | chromosome 14 open reading frame 1 | NAD(P) dependent steroid dehydrogenase-like | 0.845 |
C14orf1 | SC5DL | ENSP00000256319 | ENSP00000264027 | chromosome 14 open reading frame 1 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.889 |
C14orf1 | SIGMAR1 | ENSP00000256319 | ENSP00000277010 | chromosome 14 open reading frame 1 | sigma non-opioid intracellular receptor 1 | 0.953 |
C5orf4 | AGMO | ENSP00000320604 | ENSP00000341662 | chromosome 5 open reading frame 4 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.912 |