| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATPBD4 | C15orf41 | ENSP00000256538 | ENSP00000401362 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | chromosome 15 open reading frame 41 | 0.725 |
| ATPBD4 | C15orf53 | ENSP00000256538 | ENSP00000325144 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | chromosome 15 open reading frame 53 | 0.622 |
| ATPBD4 | DPH1 | ENSP00000256538 | ENSP00000263083 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) | 0.738 |
| ATPBD4 | DPH2 | ENSP00000256538 | ENSP00000255108 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | DPH2 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity) | 0.631 |
| ATPBD4 | DPH3 | ENSP00000256538 | ENSP00000419599 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | DPH3, KTI11 homolog (S. cerevisiae); Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity) | 0.575 |
| ATPBD4 | DPH5 | ENSP00000256538 | ENSP00000359127 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | DPH5 homolog (S. cerevisiae); S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity) | 0.735 |
| ATPBD4 | FAM98B | ENSP00000256538 | ENSP00000380734 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | family with sequence similarity 98, member B | 0.586 |
| ATPBD4 | TMCO5A | ENSP00000256538 | ENSP00000327234 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | transmembrane and coiled-coil domains 5A | 0.563 |
| ATPBD4 | UBC | ENSP00000256538 | ENSP00000344818 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | ubiquitin C | 0.799 |
| ATPBD4 | WDR85 | ENSP00000256538 | ENSP00000277540 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | WD repeat domain 85; Plays a role in the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A | 0.758 |
| C15orf41 | ATPBD4 | ENSP00000401362 | ENSP00000256538 | chromosome 15 open reading frame 41 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | 0.725 |
| C15orf41 | C15orf53 | ENSP00000401362 | ENSP00000325144 | chromosome 15 open reading frame 41 | chromosome 15 open reading frame 53 | 0.624 |
| C15orf41 | FAM98B | ENSP00000401362 | ENSP00000380734 | chromosome 15 open reading frame 41 | family with sequence similarity 98, member B | 0.623 |
| C15orf41 | TMCO5A | ENSP00000401362 | ENSP00000327234 | chromosome 15 open reading frame 41 | transmembrane and coiled-coil domains 5A | 0.564 |
| C15orf53 | ATPBD4 | ENSP00000325144 | ENSP00000256538 | chromosome 15 open reading frame 53 | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | 0.622 |
| C15orf53 | C15orf41 | ENSP00000325144 | ENSP00000401362 | chromosome 15 open reading frame 53 | chromosome 15 open reading frame 41 | 0.624 |
| C15orf53 | FAM98B | ENSP00000325144 | ENSP00000380734 | chromosome 15 open reading frame 53 | family with sequence similarity 98, member B | 0.634 |
| C15orf53 | TMCO5A | ENSP00000325144 | ENSP00000327234 | chromosome 15 open reading frame 53 | transmembrane and coiled-coil domains 5A | 0.569 |
| DPH1 | ATPBD4 | ENSP00000263083 | ENSP00000256538 | DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) | ATP binding domain 4; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (Probable) | 0.738 |
| DPH1 | DPH2 | ENSP00000263083 | ENSP00000255108 | DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) | DPH2 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity) | 0.974 |
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