node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR1C | KATNBL1 | ENSP00000243349 | ENSP00000256544 | activin A receptor, type IC; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis | katanin p80 subunit B-like 1 | 0.564 |
COIL | KATNBL1 | ENSP00000240316 | ENSP00000256544 | coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin | katanin p80 subunit B-like 1 | 0.432 |
DDX58 | KATNBL1 | ENSP00000369213 | ENSP00000256544 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | katanin p80 subunit B-like 1 | 0.489 |
EDIL3 | KATNBL1 | ENSP00000296591 | ENSP00000256544 | EGF-like repeats and discoidin I-like domains 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | katanin p80 subunit B-like 1 | 0.408 |
ELL2 | KATNBL1 | ENSP00000237853 | ENSP00000256544 | elongation factor, RNA polymerase II, 2; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells- directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition fro [...] | katanin p80 subunit B-like 1 | 0.442 |
KATNAL1 | KATNBL1 | ENSP00000369989 | ENSP00000256544 | katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity) | katanin p80 subunit B-like 1 | 0.597 |
KATNBL1 | ACVR1C | ENSP00000256544 | ENSP00000243349 | katanin p80 subunit B-like 1 | activin A receptor, type IC; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis | 0.564 |
KATNBL1 | COIL | ENSP00000256544 | ENSP00000240316 | katanin p80 subunit B-like 1 | coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin | 0.432 |
KATNBL1 | DDX58 | ENSP00000256544 | ENSP00000369213 | katanin p80 subunit B-like 1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | 0.489 |
KATNBL1 | EDIL3 | ENSP00000256544 | ENSP00000296591 | katanin p80 subunit B-like 1 | EGF-like repeats and discoidin I-like domains 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | 0.408 |
KATNBL1 | ELL2 | ENSP00000256544 | ENSP00000237853 | katanin p80 subunit B-like 1 | elongation factor, RNA polymerase II, 2; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells- directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition fro [...] | 0.442 |
KATNBL1 | KATNAL1 | ENSP00000256544 | ENSP00000369989 | katanin p80 subunit B-like 1 | katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity) | 0.597 |
KATNBL1 | PGBD4 | ENSP00000256544 | ENSP00000380872 | katanin p80 subunit B-like 1 | piggyBac transposable element derived 4 | 0.756 |
KATNBL1 | PUM1 | ENSP00000256544 | ENSP00000391723 | katanin p80 subunit B-like 1 | pumilio homolog 1 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity) | 0.538 |
KATNBL1 | PUM2 | ENSP00000256544 | ENSP00000338173 | katanin p80 subunit B-like 1 | pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts | 0.497 |
PGBD4 | KATNBL1 | ENSP00000380872 | ENSP00000256544 | piggyBac transposable element derived 4 | katanin p80 subunit B-like 1 | 0.756 |
PUM1 | KATNBL1 | ENSP00000391723 | ENSP00000256544 | pumilio homolog 1 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity) | katanin p80 subunit B-like 1 | 0.538 |
PUM2 | KATNBL1 | ENSP00000338173 | ENSP00000256544 | pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts | katanin p80 subunit B-like 1 | 0.497 |